| 不同因素对5-羟甲基糠醛含量的影响 |
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| 引用本文： | 周福富,廖爱国,刘风景,罗叶森.不同因素对5-羟甲基糠醛含量的影响[J].中国药业,2008,17(19):44-45. |
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| 作者姓名： | 周福富 廖爱国 刘风景 罗叶森 |
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| 作者单位： | 1. 金华职业技术学院,浙江,金华,321007
2. 浙江尖峰药业有限公司,浙江,金华,321000 |
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| 摘 要： | 目的探讨含葡萄糖等单糖注射液分解产物5-羟甲基糠醛（5-HMF）含量的影响因素，以提高含糖类注射液的质量。方法检测不同pH、灭菌条件及制备工艺对5-HMF含量的影响。结果灭菌温度及时间、制备方法及过程中受热时间均是影响5-HMF含量的因素。结论选择合适的灭菌温度和时间，采用合适的配制方法，可以将含糖类注射液的5-HMF含量控制在最低限度。
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| 关 键 词： | 5-羟甲基糠醛 pH 制备工艺 影响因素 |
Influence of Different Factors on 5-Hydroxymethyl Furaldehyde Content |
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| Zhou Fufu,Liao Aiguo,Liu Fengjing,Luo Yesen.Influence of Different Factors on 5-Hydroxymethyl Furaldehyde Content[J].China Pharmaceuticals,2008,17(19):44-45. |
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| Authors: | Zhou Fufu Liao Aiguo Liu Fengjing Luo Yesen |
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| Institution: | Zhou Fufu, Liao Aiguo, Liu Fengjing, Luo Yesen (1. Jinhua College of Profession and Technology, Jinhua, Zhefiang, China 321007; 2. Zhejiang Peak Pharmaceutical Co., Ltd., Jinhua, Zhefiang, China 321000) |
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| Abstract: | Objective To explore the different influencing factors to the injection decomposition product 5-hydroxymethyl furaldehyde(5-HMF) containing monosaccharide such as glucose for improving the quality.Methods The effects of different pH,antiseptic conditions and preparation technologies on 5-HMF content were investigated.Results The antiseptic temperature and time,heated time in the different preparation method and process were the factors affecting the 5-HMF content.Conclusion Choosing the appropriate antiseptic temperature and time,and adopting the proper preparation technology may control 5-HMF content of sacchariferous injections in threshold. |
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| Keywords: | 5-hydroxymethyl furaldehyde pH preparation technology influencing factor |
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