喉癌患者白细胞介素2及可溶性白细胞介素2受体的检测 |
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作者单位: | Department of Otolaryngology,Second Clinical College |
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摘 要: | 目的:观察喉癌患者的白细胞介素2(IL—2)与可溶性白细胞介素2受体(sIL—2R)水平的变化.方法:IL—2测定采用IL—2诱生及活性测定法,sIL—2R采用双抗体夹心法。结果:喉癌患者IL—2水平明显低于对照组,经统计学处理差异显著(P<0.01),而sIL—2R水平则显著增高(P<0.01),并且与喉癌的分型及分期有明显的相关性;结论:sI-2R水平测定配合IL—2测定可作为喉癌临床监测的重要指标。
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关 键 词: | 喉肿瘤 白细胞介素2 可溶性白细胞介素2受体 |
Determination of serum levels of IL-2 and soluble IL-2 receptor in laryngocacinoma patients |
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Authors: | Guan Guofang Zhao Ming Sun Liqun |
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Abstract: | Objective:Detect the levels of IL-2 and soluble IL-2 receptor in the serum of patents with laryngeal carcinoma. Methods:Detection of the level of IL-2 was done by metholds of production and activity determination of IL-2;soluble IL-2 receptor was dctermined with sandwich ELISA. Results: The level IL - 2 of patients with laryngeal carcinoma was significantly lower than that in the control group. The difference between the two groups was statistically significant (P<0. 01 ),and level of sIL-2R was higher than that of control group (P<0. 01). Activity in the level of sIL-2R was especially related to the type and clinical stage of the carcinoma. Conclusion:Determining sIL-2R levels and activity of IL-2 may be as an important index for clinical surveillance of laryngeal carcinoma. |
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Keywords: | laryngeal neoplasms IL-2 sIL -2R |
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