| 慢性粒细胞白血病对BCR-ABL酪氨酸激酶靶向抑制剂的耐药机制 |
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| 引用本文： | 肖宇航,秦群. 慢性粒细胞白血病对BCR-ABL酪氨酸激酶靶向抑制剂的耐药机制[J]. 国际病理科学与临床杂志, 2009, 29(6): 524-528 |
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| 作者姓名： | 肖宇航 秦群 |
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| 作者单位： | 中南大学,湘雅医院药剂科,长沙,410008;中南大学,药学院,长沙,410013;中南大学,湘雅医院药剂科,长沙,410008 |
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| 摘 要： | BCR-ABL酪氨酸激酶抑制剂靶向治疗慢性粒细胞白血病（chronic myeloid leukemia, CML)能够达到良好的临床效应，然而随着其临床广泛应用，对其产生耐药逐渐增多。CML细胞多药耐药是目前导致化疗失败，缓解率降低，疾病复发的主要原因。本文就CML对BCR-ABL酪氨酸激酶靶向抑制剂耐药的主要机制进行了阐述。
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| 关 键 词： | 慢性粒细胞白血病 BCR-ABL酪氨酸激酶抑制剂 多药耐药 |
| 收稿时间： | 2009-11-04 |
| 修稿时间： | 2009-12-11 |
Mechanism of drug resistance for chronic myeloid leukemia to BCR-ABL tyrosine kinase inhibitor |
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| XIAO Yuhang,QIN Qun. Mechanism of drug resistance for chronic myeloid leukemia to BCR-ABL tyrosine kinase inhibitor[J]. Journal of International Pathology and Clinical Medicine, 2009, 29(6): 524-528 |
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| Authors: | XIAO Yuhang QIN Qun |
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| Affiliation: | 1.Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008;
2.School of Pharmacy, Central South University, Changsha 410013, China |
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| Abstract: | Targeted therapy of chronic myeloid leukemia (CML) with BCR-ABL tyrosinekinase inhibitor shows a very good clinical therapeutic effect, but the drug resistancephenomena are increased with the wide use of tyrosine kinase inhibitor in clinic.Multidrug resistance is the main reason of chemotherapy failure for CML patientsaccompanied by the decrease in remission rate and the increase in relapse rate. Thisreview focus on the recent progress in the drug resistant mechanism for BCR-ABL tyrosinekinase inhibitor |
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| Keywords: | chronic myeloid leukemia BCR-ABL tyrosine kinase inhibitor multidrugresistance |
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