| 盐酸可乐定透皮贴剂家兔体外法预测其吸收率 |
| |
| 引用本文： | 莫正纪 李霞. 盐酸可乐定透皮贴剂家兔体外法预测其吸收率[J]. 华西药学杂志, 1990, 5(2): 83-84 |
| |
| 作者姓名： | 莫正纪 李霞 |
| |
| 作者单位： | 华西医科大学药学院，华西医科大学药学院，成都制药五厂中试室 成都，成都 |
| |
| 摘 要： | 中枢性作用的抗高血压药盐酸可乐定、其透皮吸收制剂称为乐百事膏,用家兔体外剩余法预测其吸收率,贴药后3小时透皮吸收累计约18%、12小时约39.7%、24小时约52.79%,贴药3天后累积吸收约60.7%。由于可乐定用药量小,有效血药浓度极低,须用较精密的分析手段才能准确测出血药浓度,应用体外剩余法可间接了解透皮吸收情况。经实验证明不失为一简单而有效的方法,具有一定的参考价值。
|
| 关 键 词： | 可乐定 透皮贴剂 吸收率 |
EVALUATION OF ABSORPTION OF CLONIDINE PASTE IN RABBIT |
| |
| Mo Zhengji,Yang Zhengwan,Li Xia School of Pharmacy,West China University of Medical Science Che?gdu Chengdu fifth Pharmaceutical factory. EVALUATION OF ABSORPTION OF CLONIDINE PASTE IN RABBIT[J]. West China Journal of Pharmaceutical Sciences, 1990, 5(2): 83-84 |
| |
| Authors: | Mo Zhengji Yang Zhengwan Li Xia School of Pharmacy West China University of Medical Science Che?gdu Chengdu fifth Pharmaceutical factory |
| |
| Abstract: | A centrally-acting An-tihypertensive agent, Clonidine, its trans-dermal form is called BAI LE SHI paste.The rate of percutaneous absorption ofpaste preparation was studies in rabbitusing an indirect method which sufficesbioavailability requirement. Mean resi-dual analysis of paste removed after 3.24and 72 hours of wear showed that cumu-lative rate of absorption were 18%,52.7% and 60.7% of the load released res-pectively. The method is proved to besimple and useful. |
| |
| Keywords: | Clonidine Absorption Transdermal form |
| 本文献已被 CNKI 维普 等数据库收录！ |
|
