L-精氨酸对慢性阻塞性肺病营养支持增效作用的探讨

目的:评价L-精氨酸对慢性阻塞性肺病(COPD)营养支持的增效作用。方法:对30例COPD患者进行营养支持治疗，总能量摄入为静息能量消耗(REE)的1．5倍，其中蛋白质占20％，脂肪30％，碳水化合物50％。12例为精氨酸治疗组，口服L-精氨酸10g，每天3次，18例为对照组，观察效果。结果:营养支持后，精氨酸组肱三头肌皮褶厚度、前白蛋白、体脂等营养参数较对照组明显改善，呼吸肌力显著提高，REE显著下降。结论:L-精氨酸不仅改善COPD的营养状况和呼吸肌力量，而且能显著降低患者的能量消耗，强化营养支持的效果，改善预后。

Enhancing effect of nutritional support of L-arginine on patients with chronic obstructive pulmonary disease

Objective To evaluate the enhancing effect of nutritional support of L-arginine on patients with chronic obstructive pulmonary disease (COPD). Methods 30 patients were randomly divided into 2 groups and observed: 12 patients in L-arginine group and 18 patients in control group. It took ten days to have the nutritional support which total calorie intake is 1.5 times of REE, while patients in L-arginine group orally took additional L-arginine 10g tid. Results Compared with control group, the nutritional parameters such as TSF, PALB and FM improved, maximal respiratory muscle strength increased and REE decreased significantly in L-arginine group. Conclusions L- arginine was helpful in the nutritional support for patients with chronic obstructive pulmonary disease, because it could enhance effects of nutritional support and reduce their energy consumption significantly and improve their nutritional status and prognosis.