| 国产注射用阿莫西林钠舒巴坦钠的急性毒性研究 |
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| 引用本文： | 张彦会,张胜利,刘浩,白玉,代志,于佩华,李新波. 国产注射用阿莫西林钠舒巴坦钠的急性毒性研究[J]. 河北医药, 2004, 26(1): 18-19 |
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| 作者姓名： | 张彦会 张胜利 刘浩 白玉 代志 于佩华 李新波 |
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| 作者单位： | 050015,河北,石家庄,华北制药集团北元有限公司;华北制药集团新药研究开发有限责任公司 |
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| 摘 要： | 目的 研究国产注射用阿莫西林钠舒巴坦钠(AMSB)对小鼠的急性毒性。方法 分别用AMSB2500mg／kg、5000mg／kg静脉注射给药和5000mg/kg腹腔注射给药对小鼠进行急性毒性试验，并与进口同种产品阿莫西林钠舒巴坦钠(TFM，商品名泰霸猛)、注射用阿莫西林钠(AM)、注射用舒巴坦钠(SB)进行了急性毒性比较。结果 国产AMSB、进口TFM、AM、SB静脉注射和腹腔注射给药对小鼠的LD50均大于5000mg／kg。结论 国产AMSB毒性很低，且与进口TFM毒性相同。
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| 关 键 词： | 阿莫西林钠 舒巴坦钠 急性毒性 小鼠 |
Study on the acute toxicity of domestic amoxicillin sodium and sulbactam sodium for injection |
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| ZHANG Yan-hui,ZHANG Shengli,UU Hao,et al.. Study on the acute toxicity of domestic amoxicillin sodium and sulbactam sodium for injection[J]. Hebei Medical Journal, 2004, 26(1): 18-19 |
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| Authors: | ZHANG Yan-hui ZHANG Shengli UU Hao et al. |
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| Affiliation: | ZHANG Yan-hui,ZHANG Shengli,UU Hao,et al. NCPC NORTH BEST CO.,LTD,Hebei,Shijiazhuang 050015 |
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| Abstract: | Objective To investigate the acute toxicity of domestic amoxicillin sodium and sulbactam sodium for injection (AMSB) in mice.Methods The acute toxicity of AMSB was observed at the doses of 2 500 mg/kg,5 000 mg/kg (iv) and 5 000 mg/kg (ip) in mice respectively, and it was compared with that of imported trifamox (TFW),amoxicillin sodium for injection (AM) ,sulbactam sodium for injection(SB) . Results By giving mice domestic AMSB,imported TFM,AM,SB intravenously or intraperitoneally.the LD50 were all larger than 5 000 mg/kg. Conclusion Domestic AMSB has little toxicity and has the similar toxicity as imported TFM. |
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| Keywords: | amoxicillin sodium sulbactam sodium acute toxicity mice |
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