胃癌患者红细胞C3b受体与淋巴细胞免疫功能的相关性研究

目的：研究胃癌患者红细胞C3b受体（RBC-C3bR）与淋巴细胞免疫功之间的关系。方法：利用酵母菌花环试验、MTT法及克隆抗体致敏花环法对51例胃癌患者及30例正常人的RBC-C3bR、自然杀伤细胞（NK）活性及T淋巴细胞（TC）亚群进行测定。结果：胃癌患者RBC-C3bR阳性率、NK细胞杀伤活性、CD3^＋、CD4^＋、CD4^＋／CD8^＋比值均比正常对照组显著低下（P〈0．05、P〈0．01）。经统计学相关性分析显示，RBC-C3bR阳性率与CD4^＋／CD8^＋比值、NK细胞杀伤活性间呈正相关（P〈0．05，P〈0．01）。结论：胃癌患者红细胞免疫功能与淋巴细胞免疫功能一样受到抑制，二者免疫功能密切联系、相互影响。

Correlation study on the C3b receptor of red blood cells and function of lymphocyte function in gastric carcinoma patients

Objective:To evaluate the correlation of red blood cells and T lymphocyte(TC) immune function in gastric carcinoma patients.Methods:The red blood C3b receptor(RBC-C3bR) rosette, natural killer(NK) cell activity and T lymphocyte subsets of 51 cases of gastric carcinoma and 30 cases of normal subjects were measured by microzyme garland test, MTT-assay and monoclonal anti-human T lymphocyte antibody.Results:Compared with the control group, RBC-C3bR, NK cell activity, CD3~+,CD4~+, ratio of CD4~+/CD8~+ were significantly lower in gastric carcinoma group(P<0.05, P<0.01); A positive correlation was observed between RBC-C3bR and NK cell activity, ratio of CD4~+/CD8~+(P<0.05, P<0.01).Conclusion:There was a close relationship between erythrocyte immune function and T lymphocyte subsets, NK cell activity.