Spontaneous release of interleukin-1 (IL-1) from medullary mononuclear cells of pagetic subjects |
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Authors: | Dr. Giulio Pioli M.D. Giuseppe Girasole Mario Pedrazzoni Paolo Sansoni Annalaura Erroi Luisa Davoli Giuseppina Ciotti Alberto Mantovani Mario Passeri |
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Affiliation: | (1) Istituto di Ricerche Farmacologiche, “Mario Negri”, Milano, Italy;(2) Clinica Medica Generale, Universitá di Parma, Via Gramsci 14, I-43100 Parma, Italy |
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Abstract: | Summary The Authors examined interleukin 1 (IL-1) secretion from the peripheral and medullary mononuclear cells, obtained with sequential separation on Ficoll-Hypaque and 45% Percoll gradient, in 6 pagetic subjects and 6 normal controls. Both peripheral and medullary cells from pagetic subjects showed a significantly greater IL-1 production after stimulation with lipopolyshaccarides (LPS); moreover, we observed a spontaneous IL-1 release from medullary cells in pagetic subjects but not in normal controls. These findings suggest a possible role of IL-1 in the elevated bone turnover of Paget's disease of bone. |
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Keywords: | Interleukin 1 Mononuclear cells Paget's disease |
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