| 依达拉奉对大鼠重症急性胰腺炎肺损伤的影响 |
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| 引用本文： | 周粼,梁道明,陈嘉勇,甘平,张家骅. 依达拉奉对大鼠重症急性胰腺炎肺损伤的影响[J]. 中国普外基础与临床杂志, 2010, 17(2): 152-155 |
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| 作者姓名： | 周粼 梁道明 陈嘉勇 甘平 张家骅 |
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| 作者单位： | 昆明医学院第二附属医院普外科,昆明,650101 |
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| 摘 要： | 目的探讨依达拉奉(edaravone)对大鼠重症急性胰腺炎(SAP)肺损伤的影响。方法36只成年SD大鼠随机分为正常对照组、模型组及依达拉奉组,每组12只,经胰胆管逆行注射5%牛磺胆酸钠建立SAP大鼠模型。依达拉奉组给予依达拉奉,正常对照组和模型组则给予等量生理盐水。术后6h处死大鼠,检测其血清和肺组织匀浆中超氧化物歧化酶(SOD)活性、丙二醛(MDA)含量,血清中肿瘤坏死因子-α(TNF-α)及白介素(IL)-1、IL-6含量,并计算肺干/湿重比(D/W)。结果模型组血清及肺组织中MDA含量以及血清TNF-α、IL-1和IL-6水平均明显高于正常对照组及依达拉奉组(P0.05),依达拉奉组血清及肺组织中MDA含量以及血清TNF-α、IL-1和IL-6水平也明显高于正常对照组(P0.05);而模型组肺D/W、血清及肺组织中SOD活性则明显低于其他2组(P0.05)。结论依达拉奉能减轻大鼠SAP导致的肺损伤。
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| 关 键 词： | 依达拉奉 重症急性胰腺炎 肺损伤 大鼠 |
Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats |
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| ZHOU Lin,LIANG Dao-ming,CHEN Jia-yong,GAN Ping,ZHANG Jia-hua. Effects of Edaravone on Lung Injury of Severe Acute Pancreatitis in Rats[J]. Chinese Journal of Bases and Clinics In General Surgery, 2010, 17(2): 152-155 |
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| Authors: | ZHOU Lin LIANG Dao-ming CHEN Jia-yong GAN Ping ZHANG Jia-hua |
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| Affiliation: | ZHOU Lin,LIANG Dao-ming,CHEN Jia-yong,GAN Ping,ZHANG Jia-hua. Department of General Surgery,The Second Affiliated Hospital of Kunming Medical College,Kunming 650101,China |
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| Abstract: | Objective To study the effects of edaravone on the lung injury of severe acute pancreatitis (SAP) in rats. Methods Thirty-six SD rats were randomly divided into three groups:normal control group,model group and edaravone group,and SAP was induced by intraductal administration of 5% sodium taurocholate. Edaravone was given in edaravone group,while normal saline was given in normal control group and model group. After operation 6 h rats were executed,and dry/wet weight (D/W) ratio of lung was counted,and malo... |
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| Keywords: | Edaravone Severe acute pancreatitis Lung injury Rat |
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