瘦素与早产儿体格生长关系的研究

目的 探讨早产儿血清瘦素(LEP)水平变化与其体格生长的关系以及疾病对早产儿血清瘦素水平的影响.方法 收集40例患中重度硬肿症、败血症、肺透明膜病、肺炎、颅内出血、窒息、消化道疾病早产儿(患病组)及30例无严重疾病早产儿(对照组)的临床资料,以放射免疫分析法检测其在不同日龄(生后第1天、第7天、第12天)时血清瘦素水平,分析不同状态早产儿体质量、身长、体重指数(BMI)等值的变化与瘦素水平变化之间的关系.结果 两组早产儿BMI及血清瘦素水平均存在出生第7天下降、第12天回升的趋势(P＜0.01),两组早产儿血清瘦素水平在不同日龄与体重指数变化呈正相关(P＜0.01).患病组早产儿血清瘦素水平在出生第7天及第12天均低于对照组(P＜0.05).结论 随着早产儿体格生长的变化,血清瘦素水平也有相应的变化,存在正相关关系;患严重疾病早产儿血清瘦索水平低于无严重疾病早产儿组,提示患严重疾病影响早产儿瘦素水平.

Study on the relationship between serum levels of leptin and physical development of premature Infants

Objective To explore the relationship between serum levels of leptin and the physieal development and the infuences of diseases on the levels of leptin in prematurities.Methods To collect the clinical data as well as weights,lengths of 40 sick premature infants(sick group)and 30 premature infants without sick diseases(control group)and to test the serum levels of leptin using radioimmunoassay(RIA)at 1d,7d and 12d of life,and to analyze the differences of serum levels of leptin and weights,lengths and body mass index(BMI)between two groups.Results In both groups the BMI and the serum levels of leptin were decreased at d7 of life and reincreased at d12 of life(P＜0.01),and the serum leptin levels were corresponding to the changes of the physical development of premature infants at ld,7d and 12d of life(P＜0.01).The serum leptin levels were lower in sick group compared with control group at 7d and 12d of life(P＜0.05).Conclusion It suggested that there was positive correlation between serum leptin level and the physieal development in prematurities and diseases had negative influences to the leptin levels.