| 小儿急性淋巴细胞白血病p16基因缺失的研究 |
| |
| 引用本文： | 吕昌龙 付国. 小儿急性淋巴细胞白血病p16基因缺失的研究[J]. 肿瘤, 2000, 20(1): 60-62 |
| |
| 作者姓名： | 吕昌龙 付国 |
| |
| 作者单位： | 吕昌龙（中国医科大学，沈阳，110001）;付国（中国医科大学，沈阳，110001）;阎建忠（中国医科大学，沈阳，110001） |
| |
| 摘 要： | 目的 了解p１６（ＭＴＳ１）基因缺失在小儿急性淋巴细胞白血病（ＡＬＬ）发病中的意 义。方法 应用ＰＣＲ和Ｓorthern印迹杂交技术检测了４７例小儿ＡＬＬ样品中p１６基因的缺失。结果 全部被检样品中有９例存在p１６基因缺失，缺失率为１９．１％。其中，８例Ｔ细胞型ＡＬＬ（Ｔ＿ＡＬＬ）中有５例显示缺失，缺失率为６２．５％；３９例前Ｂ细胞型ＡＬＬ（pre－Ｂ０－ＡＬＬ）中有４例显示缺失，缺失率为１０．３％。结论 p１
|
| 关 键 词： | 白血病 ALL 基因缺失 儿童 p16基因 |
| 文章编号： | 1000-7431(2000)01-0060-03 |
| 修稿时间： | 1998-04-08 |
INVESTIGATION OF P16(MTS1) GENE DELETION INCHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA |
| |
| LU Chang long,FU Guo,YAN Jian zhong,et al.. INVESTIGATION OF P16(MTS1) GENE DELETION INCHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA[J]. Tumor, 2000, 20(1): 60-62 |
| |
| Authors: | LU Chang long FU Guo YAN Jian zhong et al. |
| |
| Affiliation: | LU Chang long,FU Guo,YAN Jian zhong,et al.Department of Immunology,China Medical University |
| |
| Abstract: | Objective To investigate the possible relationship between p16 gene deletion and pathogenesis of pediatric acute lymphoblastic leukemia (ALL). Methods Polymerase chain reaction (PCR) and Southern blotting technique were used to analyse p16 gene deletion in DNA samples from 47 patients. Results p16 gene deletion was detected in 9 out of the total, including 5 out of 8 T ALL and 4 out of 39 pre B ALL patients. Conclusion The high frequency of p16 gene deletion might contribute to the development of pediatric ALL, especially T ALL.$$$$ |
| |
| Keywords: | Leukemia Lymphoblastic acute Gene p16 |
| 本文献已被 CNKI 维普 等数据库收录！ |
