Synchronous bilateral breast cancer: risk factors, diagnosis, histology and treatment |
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| Authors: | Marpeau O Ancel P-Y Antoine M Uzan S Barranger E |
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| Affiliation: | 1. Service de gynécologie–obstétrique, hôpital Tenon, AP–HP, CancerEst, université Pierre-et-Marie-Curie, Paris-VI, 4, rue de la Chine, 75020 Paris, France;2. Département de statistique, hôpital Tenon, AP–HP, CancerEst, université Pierre-et-Marie-Curie, Paris-VI, 4, rue de la Chine, 75020 Paris, France;3. Service d’anatomie pathologique, hôpital Tenon, AP–HP, CancerEst, université Pierre-et-Marie-Curie, Paris-VI, 4, rue de la Chine, 75020 Paris, France;4. Service de gynécologie–obstétrique, hôpital Lariboisière, AP–HP, 2, rue Ambroise-Paré, 75010 Paris, France;1. Service de gynécologie obstétrique, hôpital militaire d’instruction Mohammed V, avenue des FAR hay Riad, 10100 Rabat, Maroc;2. Service d’anatomopathologie, hôpital militaire d’instruction Mohammed V, avenue des FAR hay Riad, 10100 Rabat, Maroc;1. Pôle de gynécologie-obstétrique, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France;2. Service de pathologie professionnelle et médecine du travail, CHRU de Strasbourg, 67092 Strasbourg cedex, France;3. Unité de sénologie, CHRU de Strasbourg, avenue Molière, 67200 Strasbourg cedex, France;1. Département de gynécologie, centre hospitalier régional universitaire de Tours, hôpital Bretonneau, 2, boulevard Tonnellé, 37044 Tours, France;2. Faculté de médecine François-Rabelais, 10, boulevard Tonnellé, 37044 Tours, France;3. Département de pathologie, centre hospitalier régional universitaire de Tours, hôpital Bretonneau, 2, boulevard Tonnellé, 37044 Tours, France;4. Unité Inserm 1069, 10, boulevard Tonnellé, 37044 Tours, France;1. Unité d’oncogénétique et de prévention des cancers, service d’oncologie, hôpitaux universitaires de Genève, 30, boulevard de la Cluse, CH-1205 Genève, Suisse;2. Unité de pathologie moléculaire clinique, service de pathologie clinique, hôpitaux universitaires de Genève, 4, rue Gabrielle-Perret-Gentil, CH-1211 Genève 14, Suisse;3. Service de médecine génétique, hôpitaux universitaires de Genève, 30, boulevard de la Cluse, CH-1205 Genève, Suisse;1. Service d’oncologie médicale, hôpital militaire d’instruction Mohamed V, 10100 Rabat, Maroc;2. Service d’oncologie médicale, Institut national d’oncologie, Rabat, Maroc |
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| Abstract: | OBJECTIVE: Synchronous bilateral breast carcinoma (SBBC) is not uncommon. Women with unilateral breast carcinoma are at increased risk for developing contralateral disease. The purpose of this study was to evaluate risk factors, diagnostic circumstances, histological characteristics and therapeutic methods for SBBC. PATIENTS AND METHODS: Between July 1992 and May 2006, 62 patients with SBBC were treated at Tenon hospital (Paris, France). Population was divided into two sub-groups corresponding with two successive periods. Epidemiological characteristics, diagnostic circumstances, therapeutic methods and histological characteristics were analysed. RESULTS: Global incidence of SBBC during this period was 2.6%. The patients presenting a CSBS had a family antecedent of breast cancer in 23.7% of the cases. The most frequent situation associated a palpable tumour and an infraclinic contralateral lesion (43.5%). MRI made diagnosis possible in seven tumours. Among the patients 38.7% had a bilateral mastectomy and 33.9% profited from the technique of the ganglion sentinel. The proportions of invasive lobular carcinomas and the multifocal tumours were 17.7%. The tumours had the same histological type in 78.3% of the cases and the expression of oestrogen receptors was identical in 91.4% of the cases. DISCUSSION AND CONCLUSION: The principal risk factors of CSBS are a family history of breast cancer, the histological type lobular invasive and the multifocal character of the first tumour. A conservative surgery is possible as well as the use of the technique of the ganglion sentinel. The CSBS have histological similarities, probably due to environmental factors. |
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