亚抑菌浓度抗菌药物对细菌耐药和致病性的影响

由于药物吸收、分布和代谢过程的存在，抗菌药物治疗过程中不可避免地出现抗菌药物浓度低于感染细菌最低抑菌浓度的情况，即处于亚抑菌浓度。研究表明亚抑菌浓度的抗菌药物虽不能杀灭细菌，但可影响细菌耐药、黏附、运动和毒素的释放等生物学效应，该效应具有菌株特异性和药物特异性。亚抑菌浓度可改变细菌的致病性并影响临床感染的治疗结果，具有重要的临床意义，综述亚抑菌浓度的抗菌药物对细菌耐药和细菌致病性的影响，以期为相关研究提供参考。

Cell surface engineering of Bacillus subtilis improves production yields of heterologously expressed alpha-amylases

Due to the existence of drug absorption, distribution and metabolism, the occurrence of lower concentration of antibacterial agents than the minimal inhibitory concentration (MIC) is unavoidable in the course of antibacterial drug treatment, i e. sub-MIC. Several studies have showed that sub-MIC of antibiotics don't kill bacteria, but affect a variety of biological effects with strain specificity and drug specificity, including bacterial resistance, adhesion, movement and toxin release. Sub-MIC of antibiotics could affect the pathogenicity of bacteria and the treatment outcome of clinical infections, showing great clinical significance. In this review, the effect of sub-MIC of antibiotics on bacterial resistance and pathogenicity was reviewed, so as to provide reference for related researches.