脂质体药物递送系统的研究进展

注射剂作为一种特殊的药物剂型，具有起效快、定位准等优点，因而被广泛应用于临床。随着临床应用需求的增多，在传统注射剂的基础上，许多新型注射剂应运而生。脂质体、混悬剂、纳米粒、微球和包合物等注射给药系统的出现，不仅减少了药物在体内外的降解，还具有缓释、控释的优点，受到研究人员密切关注。重点介绍了几种新型注射剂的特点，并对国内外已上市和在研的新型注射剂进行简要介绍，旨在为其深度开发提供参考。

Diffusion of univalent ions across the lamellae of swollen phospholipids

As a special pharmaceutical dosage form, injectable products have the advantages of quick onset of action and accurate positioning, and thus have been widely used in clinical practice. With increased clinical demand, many novel injections have been developed on the basis of traditional injections. The emergence of novel injection delivery systems such as liposomes, suspensions, nanoparticles, microspheres and inclusion complexes not only reduces drug degradation in vitro and in vivo but also achieves sustained and controlled release, receiving close attention from researchers. This article focuses on the characteristics of several novel injections and briefly introduces novel injections that have been marketed or under clinical development at home and abroad, so as to provide reference for their further development.