Steroid metabolism and oestrogen receptors in human breast carcinomas |
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| Affiliation: | 1. Department of Chemical Materials and Environmental Engineering, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy;2. Department of Astronautical Electrical and Energy Engineering, Sapienza University of Rome, Via Salaria 851-881, 00138 Rome, Italy;1. College of Water Resources and Architectural Engineering, Northwest A & F University, 712100, Yangling, China;2. University of Alabama at Birmingham, Department of Mechanical Engineering, 1720 Second Ave S., Birmingham, AL, 35244, USA;3. University of Alabama at Birmingham, 1720 Second Ave S., Birmingham, AL, 35244, USA;1. Departments of Medicine, of Physiology & Pathophysiology, of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada;2. Cardiac Sciences Program, Winnipeg Regional Health Authority, Winnipeg, Manitoba, Canada |
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| Abstract: | Metabolism of7α[3H] testosterone and oestrogen receptor activity have been measured in54 human breast cancers. All tumors converted testosterone to Δ4 androstenedione,5α dihydrotestosterone and5α androstanediol, but unequivocal evidence for production of oestradiol was obtained only29 of the tumours. Thirty-seven tumours were classified as oestrogen receptor ‘positive’ containing levels in excess of5 fmol/mg cytosol protein. Although mean conversions to Δ4 androstenedione,5α dihydrotestosterone and5α androstanediol were all higher in oestrogen receptor negative tumours as compared with receptor positive group, the differences did not reach statistical significance. There was, however, a significant trend for oestradiol synthesis to be associated with oestrogen receptor positive tumours (P < 0.025). All tumours with very high level of receptors converted testosterone to oestradiol. |
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