Effects of megestrol acetate on growth and secretion of a pituitary tumor |
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| Affiliation: | 1. Nijmegen Center for Immunodeficiency and Autoinflammation (NCIA), Department of Internal Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands;2. Department of Immunology, John Radcliffe Hospital, Oxford, United Kingdom;3. Department of Clinical Immunology and Allergology, Faculty of Medicine, Masaryk University, St Anne''s University Hospital, Brno, Czech Republic;4. Department of Pulmonary Diseases, Universitat Autònoma de Barcelona, CIBER Ciberes. Barcelona, Spain;5. Donostia University Hospital, Biodonostia Health Research Institute, San Sebastian, Spain;6. Department of Clinical Immunology and Transplantology, Jagiellonian University, Medical College and Children University Hospital, Cracow, Poland;7. Department of Infectious Diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland;8. Department of Medical Oncology, Chiba University, Chiba, Japan |
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| Abstract: | The effect of the administration of the6-methylated progestagen megestrol acetate on the growth of the estrogen-induced transplantable PRL/ACTH-secreting rat pituitary tumor7315a was investigated. A significant inhibition of tumor growth was observed only during the last week of a four week period of drug administration (6 mg/kg). Administration of megestrol acetate suppressed the total content and the ability to release PRL, ACTH and LH of the pituitary gland of tumor bearing rats. Further, a significant suppression of the anterior pituitary, ovarian and uterine weights was observed in the megestrol acetate treated animals. Megestrol acetate did not exert a direct effect on PRL, ACTH and LH secretion by normal rat pituitary glands incubated in vitro.We conclude that megestrol acetate exerts in the model used a suppressive effect on PRL, ACTH and LH release and led to a diminution of the pituitary content of these hormones, while it has also anti-estrogenic and anti-androgenic properties. The effects of the drug help further explain its beneficial effects in metastatic breast, endometrial, renal and prostatic cancer in man. |
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