An objective assessment of the tube spacer in patients unable to use a conventional pressurized aerosol efficiently |
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| Affiliation: | 1. Department of Genetics and Evolution, University of Geneva, CH-1211 Geneva, Switzerland;2. School of Biology & Environmental Science, University College Dublin, Ireland;4. CIBIO/InBIO-Centro de Investigação em Biodiversidade e Recursos Genéticos, Universidade do Porto, Campus Agrário de Vairão, Rua Padre Armando Quintas, 4485–601 Vairão, Portugal; CEABN/InBIO-Centro de Estudos Ambientais ‘Prof. Baeta Neves’, Instituto Superior de Agronomia, Universidade de Lisboa, Tapada da Ajuda, 1349-017 Lisboa, Portugal;5. LifeWatch, Italy and CNR-Institute of Ecosystem Study (CNR-ISE), Largo Tonolli 50, 28922 Verbania Pallanza, Italy;6. AZTI, Marine Research Division, Herrera Kaia, Portualdea s/n, 20110 Pasaia, Spain;7. INRA, UMR42 CARRTEL, 75bis Avenue de Corzent, 74203 Thonon les Bains Cedex, France;8. Marine and Environmental Sciences Centre, Faculty of Sciences and Technology, Department of Life Sciences, University of Coimbra, Portugal;9. University of Milano Bicocca, Department of Earth and Environmental Sciences(DISAT), Piazza della Scienza 1,20126 Milano, Italy;10. Institute of Hydrobiology and Aquatic Ecosystem Management (IHG), 1180 Vienna, Austria;11. RAVON, Postbus 1413, Nijmegen 6501 BK, The Netherlands;12. Naturalis Biodiversity Center, Leiden, The Netherlands;13. School of Biological and Chemical Sciences, Queen Mary University of London, London, UK;14. Crop Research Institute, Epidemiology and Ecology of Microorganisms, Drnovska 507, 16106 Praha 6, Czechia;15. ARGE Limnologie GesmbH, Hunoldstraße 14, 6020 Innsbruck, Austria;p. Environmental Hydraulics Institute “IHCantabria”, Universidad de Cantabria, C/ Isabel Torres n°15, Parque Científico y Tecnológico de Cantabria, 39011 Santander, Spain;q. Department of Zoology, School of Natural Sciences, Trinity College Dublin, the University of Dublin, College Green, Dublin 2, Ireland; Department of Zoology, University of Otago, 340 Great King Street, Dunedin 9016, New Zealand;r. Department of Biological and Environmental Sciences and Technologies, University of Salento, S.P. Lecce-Monteroni, 73100 Lecce, Italy;s. Israel Oceanographic and Limnological Research, Tel- Shikmona, Haifa 31080, Israel;t. MARE - Marine and Environmental Sciences Centre, ISPA - Instituto Universitário, Rua Jardim do Tabaco 34, 1149-041 Lisboa, Portugal;u. IRTA, Institute of Agriculture and Food Research and Technology, Marine and Continental Waters Program, Carretera Poble Nou Km 5.5, E-43540 St. Carles de la Ràpita, Catalonia, Spain;v. Department of Limnology and Bio-Oceanography, Faculty of Life Sciences, University of Vienna, Althanstraße 14, 1090 Vienna, Austria; Senckenberg Research Institute and Natural History Museum, Senckenberganlage 25, 60325 Frankfurt am Main, Germany;w. Botanic Garden and Botanical Museum Berlin-Dahlem, Freie Universität Berlin, Königin-Luise-Str. 6-8, 14195 Berlin, Germany;x. University of Duisburg-Essen, Aquatic Ecosystem Research, Universitaetsstrasse 5, 45141 Essen, Germany;y. Musée National d''Histoire Naturelle, 25 Rue Münster, 2160 Luxembourg, Luxembourg;z. Swedish University of Agricultural Sciences, Department of Aquatic Sciences and Assessment, PO Box 7050, SE - 750 07 Uppsala, Sweden |
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| Abstract: | The tube spacer, a device designed to simplify the inhalation of terbutaline from a pressurized aerosol, was objectively assessed in a group of patients with reversible airways obstruction who were found to have some difficulty in using conventional inhalers. Terbutaline was administered to 22 patients in a dose of 250 μg via the conventional pressurized aerosol and the tube spacer. In 16 the improvements in FEV1 were greater after the tube spacer, in four they were greater after the conventional inhaler and in two patients there was no difference. Using an open sequential plan for evaluation of paired preferences it was concluded that the tube spacer was better than the conventional inhaler in these patients. |
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