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全球糖尿病治疗药物研发及市场态势
引用本文:李子艳, 王春丽, 高柳滨. 全球糖尿病治疗药物研发及市场态势[J]. 药学进展, 2018, 42(9): 710-717.
作者姓名:李子艳  王春丽  高柳滨
作者单位:中国科学院上海药物研究所信息中心,上海 201203
基金项目:中国科学院战略性先导科技专项(No.XDA12050201)
摘    要:

糖尿病是常见慢性代谢性疾病,随着我国人口老龄化与生活方式的变化,糖尿病从少见病变成一个流行病,糖尿病患病率从1980年的0.67%飙升至2017年的10.9%,当前,糖尿病具有患病率高、病情不可逆和后期并发症多的特点。除了生活方式干预疗法,包括饮食和锻炼计划外,药物治疗仍是糖尿病治疗的重要方法之一。尽管目前已有多种不同机制的降糖药物,但是63%的2型糖尿病患者仍然得不到有效的治疗,因此开发糖尿病治疗创新药物仍是当务之急。综述了全球糖尿病治疗药物的数量、研发阶段、药物靶点及作用机制、研发机构和销售等情况,展望糖尿病药物研发前景。



关 键 词:糖尿病  药物研发  药物靶点  研发机构  个性化药物

Prevalence of diabetes among men and women in China
LI Ziyan, WANG Chunli, GAO Liubin. Global Report on R & D and Marketing Trend of Anti-diabetic Drugs[J]. Progress in Pharmaceutical Sciences, 2018, 42(9): 710-717.
Authors:LI Ziyan  WANG Chunli  GAO Liubin
Affiliation:Information Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China
Abstract:Diabetes is a common chronic metabolic disease. With the aging population and lifestyle changes in China, diabetes has changed from a rare disease into an epidemic disease, with the prevalence rate soaring from 0.67% in 1980 to 10.9% in 2017. At present, diabetes mellitus is characterized by high prevalence, irreversible condition and diverse late complications. In addition to lifestyle intervention including diet and exercise program, drug therapy is still one of the important methods of treating diabetes. Although many hypoglycemic drugs with different mechanisms are currently available, 63% of patients with type 2 diabetes still can't be effectively treated, consequently, the development of innovative antidiabetic drugs is still a priority. This article reviewed the numbers, development stages, therapeutic targets and mechanisms, as well as research institutions and sales of antidiabetic drugs from a global perspective, forecasting the new trend in the development of antidiabetic drugs.
Keywords:diabetes  drug R & D  drug target  R & D institution  personalized drug
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