| 临床阿司匹林抵抗机制研究 |
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| 引用本文： | 侍冬成,封启明. 临床阿司匹林抵抗机制研究[J]. 心血管病学进展, 2008, 29(1): 157-160 |
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| 作者姓名： | 侍冬成 封启明 |
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| 作者单位： | 上海交通大学附属第六人民医院急诊科,上海,200233 |
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| 摘 要： | 阿司匹林在心肌梗死、缺血性脑血管病的预防中是一种有效的抗血小板药物.但在长期随访中发现,应用阿司匹林治疗的冠心病患者仍有可能发生血栓栓塞事件,这称为临床阿司匹林抵抗.现分析了人体内血栓形成时血小板所处的环境,阿司匹林的作用机制及环氧化酶(COX)的生物学功能,并着重分析了临床阿司匹林抵抗的可能机制.
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| 关 键 词： | 阿司匹林抵抗 血小板聚集 环氧化酶 血栓素A2 临床 阿司匹林 抵抗 机制研究 Resistance Aspirin Clinical Mechanism 可能机制 生物学功能 氧化酶 作用 环境 体内血栓形成 分析 血栓栓塞事件 发生 冠心病患者 治疗 应用 |
| 文章编号： | 1004-3934（2008）01-0157-04 |
| 收稿时间： | 2007-02-27 |
| 修稿时间： | 2007-07-03 |
Studies of Mechanism of Clinical Aspirin Resistance |
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| SHI Dong-cheng,FENG Qi-ming. Studies of Mechanism of Clinical Aspirin Resistance[J]. Advances in Cardiovascular Diseases, 2008, 29(1): 157-160 |
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| Authors: | SHI Dong-cheng FENG Qi-ming |
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| Abstract: | Aspirin is an effective antiplatelet drug used to prevent myocardial infarction and isehaemie cerebrovascular events. However, long-term observations have shown that there are patients on aspirin who still suffer thromboembolism events. This is called clinical aspirin resistance. This review analyses the environment in which platelets stay when thrombokinesis occurs, the mechanism of action of aspirin, the biological function of cyclooxygenase, and focuses on the possible meehanisln of clinical aspirin resistance. |
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| Keywords: | aspirin resistance platelet aggregation cyelooxygenase thromboxane A2 |
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