Myasthenia gravis antibodies to skeletal muscle cell surface antigens |
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Authors: | Nils Erik Gilhus Johan A. Aarli Roald Matre |
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Affiliation: | 1. Department of Neurology, University of Bergen, Bergen, Norway;2. Broegelmann Research Laboratory for Microbiology, University of Bergen, Bergen, Norway |
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Abstract: | Sera from 28 of 137 patients with myasthenia gravis (MG) (i.e. 20%) contained antibodies which stained the surface of skeletal muscle cells in an indirect immunofluorescence test. Forty of the 137 sera (i.e. 30%) contained cross-striational antibodies. Absorption experiments showed that the antibodies staining the muscle cell surface were different from those staining the cross-striational bands. Twenty of the sera (i.e. 15%) contained antibodies which agglutinated sheep erythrocytes (SE) coated with a citric acid extract of skeletal muscle (CAE). These antibodies were closely associated with the presence of a thymoma. There was a positive correlation between the antibodies agglutinating CAE-coated SE and those staining the muscle cell surface. Absorption experiments indicated that the antibodies to CAE were directed against muscular antigens located in or near the sarcolemma. |
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Keywords: | Myasthenia gravis Sarcolemma Skeletal muscle antibodies Thymoma |
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