| Depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats |
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| 作者姓名： | 左克强 钱振宇 黄道景 龚凯 汤敬东 |
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| 作者单位： | Department of Vascular Surgery Tongji Hospital，Tongji University，Department of Vascular Surgery，Tongji Hospital，Tongji University，Department of Vascular Surgery，Tongji Hospital，Tongji University，Department of Vascular Surgery，Tongji Hospital，Tongji University，Department of Vascular Surgery，Tongji Hospital，Tongji University，Shanghai 200065，China，Shanghai 200065，China，Shanghai 200065，China，Shanghai 200065，China，Shanghai 200065，China |
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| 摘 要： | Objective To investigate the depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats. Methods： The models of abdominal aorta transplantation were made with micro-surgery in rats. The recipients were divided into three groups： allograft control group, atorvastatin-treated group and isograft control group. Vascular intimal thickness in all of the groups were observed by histological examination. The expression of PCNA and α-SMA were determined by immunohistochemistry. The content of nitric oxide was determined by nitrate reductase chromatometry. Results： The vascular intimal thickness in rats of atorvastatin-treated group （11.60% ± 2.40% ） were lower than those in allograft control group （34.60 % ± 6.40 % ; P 〈 0.05） and higher than those in isograft control group （1.15 % ± 0.65 %; P〈 0.05 ）. The expression level of PCNA was decreased in atorvastatin-treated group （4.80% ± 0.80% ） than allograft control group （18.40% ± 1.80% ; P〈0.05） and higher than isograft group （1.20% ± 0.40% ; P〈0.05）. Conclusion： The expression of PCNA in the transplant aorta could be suppressed by atorvastatin, which resalted in relief of chronic rejection of aortic allograft.
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| 关 键 词： | 慢性排斥 细胞增生 平滑肌 镇静剂 动脉移植 |
Depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats |
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| Zuo Keqiang Qian Zhenyu Huang Daojing Gong Kai Tang Jingdong.Depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats[J].China Medical Abstracts,2008,17(2):160-163. |
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| Authors: | Zuo Keqiang Qian Zhenyu Huang Daojing Gong Kai Tang Jingdong |
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| Institution: | Department of Vascular Surgery, Tongji Hospital, Tongji University, Shanghai 200065, China |
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| Abstract: | Atorvastatin Transplant Chronic rejection Proliferation cell nuclear antigen α-smooth muscle actin Nitric oxide |
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| Keywords: | Atorvastatin Transplant Chronic rejection Proliferation cell nuclear antigen α-smooth muscle actin Nitric oxide |
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