腹腔镜单侧卵巢子宫内膜异位囊肿剥除术对血清抗苗勒管激素水平变化的影响

目的:探讨腹腔镜下单侧卵巢子宫内膜异位囊肿剥除术对血清抗苗勒管激素(AMH)变化的影响。方法:测定128例单侧卵巢囊肿患者手术前及术后1周、3个月及6个月的AMH、FSH及E_2水平,并进行窦卵泡计数。结果:术后1周,AMH、FSH及E_2均发生改变,且差异有统计学意义(P0.05);术后3个月,血FSH和E_2水平已恢复正常,窦卵泡计数与术前无明显改变(P0.05),但AMH水平仍低于术前(P0.05);术后第6个月,AMH水平仍低于术前水平(P0.05),而FSH、E_2及窦卵泡数均较术前比较,差异无统计学意义(P0.05)。年龄35岁患者的术后AMH下降率显著高于年龄≤35岁者(P=0.001)。结论:单侧囊肿卵巢囊肿术后半年卵巢储备功能仍处于恢复阶段,AMH可作为敏感的卵巢储备标志物,优于基础FSH测定及窦卵泡计数。

Effect on serum anti-Müllerian hormone in women with unilateral ovarian endometriotic cyst after laparoscopic ovarian cystectomy

Objective:To explore the effect on serum anti-Müllerian hormone ( AMH) in women with unilateral ovarian endometriotic cyst after laparoscopic ovarian cystectomy. Methods:A total of 128 women with unilateral ovarian endometriotic cyst unergoing Laparo-scopic cystectomy were included. Serum AMH,FSH and E2 levels before and after surgery were detected. Meanwhile,antral follicles were calculated. Results:A week after the surgery, serum AMH,FSH and E2 levels changes with statistical significance when compared to those before surgery(P<0. 05). At the third month after the surgery,serum FSH and E2 level and antral fol-licles returned to their original condition,while serum AMH level was still lower than that before surgery(P<0. 05). At the sixth month after the surgery,serum FSH and E2 level and antral fol-licles have no difference when compared to those before surgery (P>0. 05),while serum AMH level was still lower than that before surgery(P<0. 05). In addition,AMH in patients with age>35 years old decreased obviously than that in patients with aged ≤35 years(P=0. 001). Con-clusion:Ovarian reserve function is still in the recovery phase at the sixth month after unilater-ally laparoscopic ovarian endometriotic cystectomy. AMH can be used as a more sensitive mark-er of ovarian reserve than basal FSH level and antral follicles count.