Respective roles of TLR, RIG-I and NLRP3 in influenza virus infection and immunity: impact on vaccine design |
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Authors: | Ichinohe Takeshi |
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Institution: | Department of Virology, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ichinohe@virology.med.kyushu-u.ac.jp |
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Abstract: | Influenza A virus is the etiological agent of a highly contagious acute respiratory disease that causes epidemics and considerable mortality annually. It has become increasingly evident that influenza viral infection is recognized by at least three classes of pattern-recognition receptors, including TLR-7, the retinoic acid inducible gene-I and nucleotide-binding domain and leucine-rich-repeat-containing protein 3, a member of the Nod-like receptor family. This article highlights the roles of different types of innate immune receptors in influenza virus immunity versus immunopathology. |
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