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| 罗沙替丁乙酸酯衍生物的合成和抗溃疡活性的研究 | |
| 引用本文： | 张辉,张倩云,袁权. 罗沙替丁乙酸酯衍生物的合成和抗溃疡活性的研究[J]. 沈阳医学院学报, 2009, 11(1): 26-27,33 |
| 作者姓名： | 张辉 张倩云 袁权 |
| 作者单位： | 1. 沈阳医学院基础医学院化学教研室,辽宁,沈阳,110034 2. 中国医科大学93期预防化学专业 3. 中国医科大学92期临床医学专业 |
| 摘 要： | 目的：合成一系列的罗沙替丁乙酸酯衍生物。方法：以间羟基苯甲醛为起始原料，合成H2－受体拮抗剂罗沙替丁乙酸酯盐酸盐。结果：其结构经^1H—NMR，MS表征，并显示出一定的抗溃疡活性。结论：结果表明6b有较好的活性。 |
| 关 键 词： | 罗沙替丁乙酸酯 衍生物 合成 H2－受体拮抗剂 |
Synthesis and characterization of the derivatives of roxatidine and study of activity |
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| ZHANG Hui,ZHANG Qian-yun,YUAN Quan. Synthesis and characterization of the derivatives of roxatidine and study of activity[J]. Journal of Shenyang Medical College, 2009, 11(1): 26-27,33 | |
| Authors: | ZHANG Hui ZHANG Qian-yun YUAN Quan |
| Affiliation: | 1. Chemistry department of basic school of Shenyang medical college, Shenyang, China 110034 ; 2. No 93 preventive medicine major, China Medi- cal University, Shenyang 110001, China; 3. No 92 clinical medicine major, China Medical University) |
| Abstract: | Objective： To design and synthesize the derivative of roxatidine. Methods： Roxatidine acetate were synthesized from 3-hydroxy benzaldehyde by a series of reaction. Results： The structure of the product was confirmed by IR.^1H - NMR and MS. They have antiulcer activity slightly. Conclusion： Pharmacological tests showed that 6b had higher percent of inhibition ability on gastric juice acid output. |
| Keywords: | roxatidine derivatives synthesis histamine H2-receptor antagonist. |
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