| 利培酮与氯丙嗪治疗难治性精神分裂症对照研究 |
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| 引用本文： | 冯春霞,黄世勋,等.利培酮与氯丙嗪治疗难治性精神分裂症对照研究[J].山东精神医学,2001,14(2):95-96. |
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| 作者姓名： | 冯春霞 黄世勋 |
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| 作者单位： | 冯春霞（256612,山东省滨州市复退军人医院）
黄世勋（256612,山东省滨州市复退军人医院）
杨洪志（256612,山东省滨州市复退军人医院）
陈九义（256612,山东省滨州市复退军人医院）
刘和祥（256612,山东省滨州市复退军人医院） |
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| 摘 要： | 目的：比较利培酮与氯丙嗪治疗难治性精神分裂分裂症的疗效。方法：将符合入组条件的病人随机分为2组，分别服用利培酮或氯丙嗪治疗12周，用阳性与阴性症状量表（PANSS）和副反应量表（TESS）评定疗效和副反应情况。结果：利培且总有效率为71．4％，明显高于氯丙嗪组42．9％，经统计学处理差异有显著性（P＜0．05），结论：利培酮对难治性精神分裂症的 疗效优于氯丙嗪，对阴性症状效果更佳。
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| 关 键 词： | 利培酮 氯丙嗪 难治性精神分裂症 治疗 |
A comparative trial on the efficacy of risperidone vs chlorpromazine in treatment- resistant schizophrenia. |
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| Feng Chunxia,Huang Shixun,Yang Hongzhi,et al..A comparative trial on the efficacy of risperidone vs chlorpromazine in treatment- resistant schizophrenia.[J].Shangdong Archives of Psychiatry,2001,14(2):95-96. |
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| Authors: | Feng Chunxia Huang Shixun Yang Hongzhi |
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| Institution: | Feng Chunxia,Huang Shixun,Yang Hongzhi,et al. Binzhou Demobilized Soldiers Hospital,256612 |
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| Abstract: | Objective To compare the efficacy of risperidone with that of chlorpromazine in patients with treatment -resistant schizophrenia. Methods Patients with diagnosis of treatment - resistant schizophrenia were randomly assigned to two grorps that were treated with either risperidone or chlorpromazine for 12 weeks . The therapeutic response and side effects were evaluated with the PANSS and TESS. Results The overall therapeutic effect of risperidone (71.4%) was superior to that of chlorpromazine (42.9%). There were statistical differences in the PANSS total scores and N or G scale scores between the two groups (P < 0.05).Conclusion Risperidone is superior to chlorpromazine in the treatment - resistant schizophrenia, especially those with more negative symptoms. |
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| Keywords: | Risperidone Chlorpromazine Treatment - resistant schizophrenia |
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