The dose-response effects of caffeine on sleep in rats |
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| Authors: | G Yanik S Glaum M Radulovacki |
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| Institution: | 1. Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Rigshospitalet, University of Copenhagen, Denmark;2. Department of Oncology, Section of Radiotherapy, Rigshospitalet, University of Copenhagen, Denmark;3. Department of Clinical Physiology, Nuclear Medicine & PET, PET & Cyclotron Unit, Rigshospitalet University of Copenhagen, Denmark;4. Division of Biostatistics and Bioinformatics, University of Maryland Greenebaum Cancer Center, and Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, USA;1. New York University Abu Dhabi, P. O. Box 129188, Saadiyat Island, Abu Dhabi, United Arab Emirates;2. International Centre for Diffraction Data, Newtown Square, Pennsylvania, United States;1. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;2. Essentia Institute of Rural Health, Duluth, MN, USA;1. Hypertension Unit, Department of Clinical and Experimental Medicine, University of Pisa, Via Roma 67, 56127 Pisa, Italy;2. Rheumatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy;3. Institute of Clinical Physiology, CNR, Pisa, Italy;4. GenOMeC PhD, University of Siena, Italy;1. Vilnius University Medical Faculty, Vilnius, Lithuania;2. Vilnius University Centre of Cardiology and Angiology, Vilnius, Lithuania;3. State Research Institute for Inovative Medicine, Vilnius, Lithuania |
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| Abstract: | Caffeine at doses of 0.125, 1.25, 12.5 and 25 mg/kg was administered to rats and the subsequent effects on the sleep-wake cycle were measured. The 12.5 and 25 mg/kg doses of caffeine increased wakefulness, and decreased slow wave sleep-1 (SWS1), SWS2, rapid eye movement (REM) sleep and total sleep time (P less than or equal to 0.05). The 0.125 and 1.25 mg/kg doses of caffeine increased SWS1 at the expense of SWS2 (P less than or equal to 0.05), and did not affect total sleep time in any time period measured. Adenosine or adenosine agonists have been shown to increase SWS2 at the expense of waking or SWS1 with an increase in total sleep time. The effects of caffeine on sleep reported in this study suggest that caffeine administration not only antagonizes the effects of adenosine at the receptor level, but also at the behavioral level. |
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