静脉注射胺碘酮在快速性心律失常中的作用及药物不良反应分析

目的观察胺碘酮静脉注射对快速性心律失常的疗效，探讨其药物不良反应防治措施。方法24例患者均应用150mg胺碘酮注射液加生理盐水20ml，10-15min内缓慢射注，后以1．0mg/min持续静脉滴注6h，再以0．5mg／min的剂量缓慢静脉滴注或微量泵入，维持18h，观察其转复效果、心室率控制及药物不良反应，并对其不良反应进行及时处理。结果本组病例胺碘酮转复心律失常显效率66．7％，转复率91．7％，减慢心室率100％。不良反应：15例出现不同程度的血压降低，明显降低（小于90／60mmHg）2例（1mmHg=0．133kPa），出现注射血管静脉炎4例，心动过缓4例，Q-T间期延长2例。经积极处理，无严重后果。结论胺碘酮静脉注射治疗快速性心律失常迅速、有效，可用于治疗和抢救快速性心律失常危重症；通过一系列不良反应防治措施，可提高其安全使用度。

Curative effect and adverse reaction of intravenous injection of amidarone in tachycardia arrhythmias

Objective To observe the curative effect and adverse reaction of intravenous injection of amidalone iu treating Tachycardia Arrhythmias.Methods Twenty.four patients witll tachycardia arrhythmias were administrated with intravenous amiodarone for cardioversion.and the cardioversion rate,control effect of ventricular rate and the adverse reaction were observed.Results The effective rate of amidarone in treating arrhythmias was 66.7%,the cardioversion rate of arrhythmia was 91.7%,and ventricular rate was slowed down in all cases.The adverse reaction included hypotension(15 cases,cases＜90/60 mm Hg),phlebitis(4 cases),bradycardia(4 cases) and prolonged Q-T interval(cases),but no semus aftermath Was result in after appropriate treatment.Conclusion The application of intravenous injection of amidarone in treating Tachycardia Arrhythmias was safe,rapid and effec tive.And the safety of intravenous amiodarone could be ensured by appropriate prevention measure of adverse reaction.