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| S100A4蛋白在肝癌组织中的表达及临床意义 | |
| 引用本文： | 郝向芳,李红,葛超,胡晨,陈陶阳,李锦军. S100A4蛋白在肝癌组织中的表达及临床意义[J]. 肿瘤, 2008, 28(11). DOI: 10.3781/j.issn.1000-7431.2008.11.011 |
| 作者姓名： | 郝向芳 李红 葛超 胡晨 陈陶阳 李锦军 |
| 作者单位： | 1. 上海交通大学肿瘤研究所癌基因及相关基因国家重点实验室,上海,200032 2. 浙江大学附属第一医院普外科,杭州,310003 3. 启东肝癌防治研究所,启东,226200 |
| 基金项目： | 国家自然科学基金，上海市卫生局资助项目 |
| 摘 要： | 目的:探讨SIOOA4蛋白在肝细胞癌、肝硬化、癌旁组织及正常肝组织中的表达及临床意义.方法:用组织芯片技术结合免疫组织化学法检测S100A4蛋白在肝癌相关组织中的表达差异,采用统计学方法分析其表达差异的临床意义.结果:免疫组织化学检测发现,S100A4蛋白在人原发性肝细胞癌、硬化肝组织、癌旁肝组织中表达较高,在正常肝组织中表达则很低,表达阳性率分别为70.2%、54.4%、41.7%和0.0%;统计学分析结果表明,S100A4蛋白表达影响肝癌患者的术后生存期,低表达患者的生存期比高表达患者延长.结论:S100A4蛋白在肝癌及相关组织中的表达率依次为,肝细胞癌＞癌旁肝＞肝硬化＞正常肝,在非微血管侵袭肝癌患者中S100A4阳性表达可明显降低其术后生存率. |
| 关 键 词： | 癌,肝细胞 免疫组织化学 S100A4蛋白 |
Expression of S100A4 protein in hepatocellular carcinoma and its clinical implications |
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| HAO Xiang-fang,LI Hong,GE Chao,HU Chen,CHEN Tao-yang,LI Jin-jun. Expression of S100A4 protein in hepatocellular carcinoma and its clinical implications[J]. Tumor, 2008, 28(11). DOI: 10.3781/j.issn.1000-7431.2008.11.011 | |
| Authors: | HAO Xiang-fang LI Hong GE Chao HU Chen CHEN Tao-yang LI Jin-jun |
| Affiliation: | HAO Xiang-fang1,LI Hong1,GE Chao1,HU Chen2,CHEN Tao-yang3,LI Jin-jun1(1.State Key Laboratory of Oncogenes & Related Genes,Shanghai Cancer Institute,Shanghai Jiaotong University,Shanghai 200032,China,2.Department of General Surgery,First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,3.Qidong Liver Cancer Institute,Qidong 226200,China) |
| Abstract: | Objective:To explore the expressions of S100A4 protein in hepatocellular carcinoma(HCC),cirrhotic liver,adjacent non-cancerous liver and normal liver tissues and their clinical implications.Methods: Tissue microarray combined with immunohistochemistry(IHC) was used to evaluate the differential expressions of S100A4 protein in HCC-related tissues,and their clinical implications were statistically analyzed.Results: Immunohistochemical staining showed that the positive staining of S100A4 protein was higher in ... |
| Keywords: | Carcinoma hepatocellular Immunohistochemistry S100A4 protein |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |