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| Resolution of Crohn’s disease and complex regional pain syndrome following treatment of paratuberculosis | |
| 作者姓名： | J Todd Kuenstner William Chamberlin Saleh A Naser Michael T Collins Coad Thomas Dow John M Aitken Stuart Weg Grzegorz Telega Kuruvilla John David Haas Torsten M Eckstein Maher Kali Christine Welch Thomas Petrie |
| 作者单位： | Department of Pathology,Charleston Area Medical Center,Charleston,WV 25304,United States;Department of Gastroenterology,Mountain View Regional Hospital,Las Cruces,NM 88011,United States;Burnett School of Biomedical Sciences,UCF College of Medicine,Orlando,FL 32816,United States;Department of Pathobiological Sciences,the University of Wisconsin School of Veterinary Medicine,Madison,WI 53706,United States;5 Damon Street,Eau Claire,WI 54701,United States;Otakaro Pathways Ltd.,63 Bibiana Street,Christchurch 8011,New Zealand;Patients Medical,Alternative Pain Management,800 Second Avenue Suite 900,New York City,NY 10017,United States;Children’s Hospital of Wisconsin,8915 W.Connell Ave.,Milwaukee,WI 53226,United States;Department of Neurosciences,Charleston Area Medical Center,Charleston,WV 25304,United States;Department of Chemistry,University of Charleston,Charleston,WV 25304,United States;Department of Microbiology,Colorado State University,Immunology and Pathology,CO 80523,United States;CAMC Clinical Trials Center,3100 Mac Corkle Avenue S.E.,Suite 806,Charleston,WV 25304,United States;CAMC Clinical Trials Center,Charleston,WV 25304,United States;AVIcure Bioscience LLC,Superior Quartz Products,Bethlehem,PA 18020,United States |
| 摘 要： | A cohort of family members with various chronic diseases including Crohn’s disease, asthma, complex regional pain syndrome, hypothyroidism, type 1 diabetes mellitus, and lymphangiomatosis and/or evidence of infection by Mycobacterium avium subsp. paratuberculosis(MAP) are described in this series of case reports. MAP was cultured from the blood of three members affected by the first five diseases and there was accompanying elevated anti-MAP Ig G in two members. The patient affected by the sixth disease has a markedly elevated anti-MAP titer. The two patients affected by the first four diseases have been treated with a combination of anti-MAP antibiotics and ultraviolet blood irradiation therapy with resolution of the disease symptomatology and inability to culture MAP in post treatment blood samples. These case reports of patients with MAP infections provide supportive evidence of a pathogenic role of MAP in humans. |
| 关 键 词： | Crohn’s disease Complex regional pain syndrome Lymphangiomatosis Mycobacterium avium paratuberculosis Cure |
| 收稿时间： | 2014-10-22 |
| 本文献已被 CNKI 等数据库收录！ | |