乌司他丁联合参麦注射液治疗急性胰腺炎相关肺损伤的临床研究

目的 观察乌司他丁联合参麦注射液对急性胰腺炎相关急性肺损伤的临床治疗效果.方法 选取急性胰腺炎相关肺损伤患者60例,随机分为乌司他丁＋参麦组（US组）、乌司他丁组（U组）和对照组（C组）,每组20例.C组给予常规治疗,U组在常规治疗基础上每日静脉滴注乌司他丁（6000U/kg）,US组在常规治疗基础上每日静脉滴注乌司他丁（6000U/kg）和参麦注射液（0.6ml/kg）.分别于治疗前、治疗后第3、7天行动脉血气分析,计算氧合指数,测定血清TNF-α、IL-1β和IL-6浓度.结果 与C组比较,U组和US组治疗后3和7天血清TNF-α、IL-1β和IL-6浓度下降,治疗后7天氧合指数升高（P＜0.05）;与U组比较,US组治疗后7天血清TNF-α、IL-1β和IL-6浓度下降,氧合指数升高（P＜0.05）.结论 乌司他丁联合参麦注射液能进一步抑制炎性介质释放,减轻急性胰腺炎相关肺损伤.

Clinical Study on Ulinastatin Combined with Shenmai Injection in Attenuating Lung Injury Associated with Acute Pancreatitis

Objective To study the therapeutic effects of Ulinastatin combined with Shenmai injection on acute lung injury associated with acute pancreatitis.Methods Sixty patients diagnosed associated as acute pancreatitis complicated with lung injury were enrolled and randomized into Ulinastatin ＋ Shenmai （US） Group,Ulinastatin （U） Group and Control （C） Group.The patients in C Group received conventional therapy,while extra intravenous administration of Ulinastatin （6000U/kg,1 time per day） was given in U Group,and additional Shenmai injection （0.6ml/kg,1 time per day） was given in US Group based on same therapy received in U Group.The concentrations of serum TNF-α,IL-1β and IL-6 were measured,and blood gases were detected before therapy initiation,3d and 7d after therapy.Results As compared to C Group,the levels of serum TNF-α,IL-1β and IL-6 were decreased at 3d and 7d post-therapy,and oxygenation index at 7d post-therapy was enhanced （P ＜ 0.05）.serum TNF-α,IL-1 β and IL-6 levels at 7d post-therapy were lower and oxygenation index was higher in US Group than those in U Group,respectively （P ＜ 0.05）.Conclusion Treatments of Ulinastatin combined with Shenmai injection could further inhibit the release of inflammatory cytokines and attenuate lung injury in patients with acute pancreatitis.