Diabetes enhances vasoreactivity to calcium entry blockers |
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| Authors: | G M Pieper G J Gross |
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| Affiliation: | Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee 53226. |
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| Abstract: | Equipotent concentrations of diltiazem and verapamil relaxed coronary resistance vessels in isovolumically-perfused rat hearts. In diabetic hearts, the vasodilator response to diltiazem, and to a lesser extent verapamil, was significantly augmented. The addition of both calcium entry blockers also produced greater relaxation in precontracted isolated thoracic aorta of diabetic animals suggesting that diabetes increases the sensitivity of calcium entry blockers in two separate vessel types. |
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