| 硕苞蔷薇化学成分对抗吗啡戒断症状的实验研究 |
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| 引用本文： | 陈艳明,田育望. 硕苞蔷薇化学成分对抗吗啡戒断症状的实验研究[J]. 湖南中医药大学学报, 2000, 20(1): 6-7,11 |
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| 作者姓名： | 陈艳明 田育望 |
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| 作者单位： | 1. 湖南中医学院,湖南,长沙,410007
2. 湖南中医学院,药理研究室,湖南,长沙,410007 |
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| 基金项目： | 湖南省自然科学基金!98 JJY 2022，湖南省教委!97 B 091，湖南省卫生厅中医管理局!98006 |
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| 摘 要： | 为研究硕苞蔷薇３种化学成分ＲＢａ，ＲＢｂ，ＲＢｃ对抗吗啡成瘾小鼠戒断症状的作用，以筛选有效化学成分，并对其身体依赖性作出评价。结果表明，ＲＢａ能明显对抗吗啡成瘾小鼠由纳络酮催促的跳跃反应，与模型组比较，跳跃次数明显减少，跳跃率明显下降，而ＲＢｂ，ＲＢｃ跳跃次数和跳跃率均无明显差异；且ＲＢａ能明显提高小鼠痛阈值，减少扭体反应次数，与生理盐水组比较均有极显著差异，但作用比吗啡弱。
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| 关 键 词： | 硕苞蔷薇 吗啡戒断症状 化学成分 |
An Experimental Study on the Effects of the Chemical Compounds of Rosa Bracteata Wendl.against Morphine Withdrawal Syndromes in Mice |
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| Chen Yanming,Tian Yuwang. An Experimental Study on the Effects of the Chemical Compounds of Rosa Bracteata Wendl.against Morphine Withdrawal Syndromes in Mice[J]. Journal of Traditional Chinese Medicine University of Hunan, 2000, 20(1): 6-7,11 |
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| Authors: | Chen Yanming Tian Yuwang |
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| Abstract: | The effects of 3 kinds of chemical compounds of Rosa bracteata Wendl. RBa.RBb.RBc against morphine withdrawal syndromes in mice were studied and the effective chemical compound and its physiological dependence were cribrated and evaluated. The results showed that, RBa could obviously antagonist the jumping reaction of morphine abusing mice after i. p naloxone to urge the addiction; compared with the control group,RBa reduced jumping times and jumping rate(P 0. 05), RBa could also increase the pain threshold, reduce the times of turning - around reaction(P
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| Keywords: | Rosa bracteata Wendl Morphine Addiction withdrawal syndrome |
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