急性颅脑损伤后血清内源性类洋地黄物质含量变化

目的 探讨颅脑损伤后血清内源性类洋地黄物质（ＥＤＬＳ）含量变化及其机理和临床意义。方法 采用放免法检测６３例急性颅脑外伤患者血清ＥＤＬＳ浓度变化，对其中１９便作动态观测，１６例行手术前后对比，２３例与预后进行相关分析。结果 不同程度脑外伤皇２４小时内血清ＥＬＤＳ均升高，以轻伤组最为典型；随着损伤程度的加剧，少数病例ＥＤＬＳ不变甚至下降，术后或随伤情的恢复，ＥＤＬＳ多同步下降，不同病病理类型的脑损伤

Changes of serum EDLS contents after acute craniocerebral injury

Objective To investigate the content change of endogenous digitalis like substance(EDLS) in serum after acute craniocerebral injury,its mechanism and clinical significance.Methods Content change of serum EDLS in 63 cases of acute craniocerebral injuries was investigated by radioimmunoassay (RIA), 19 cases of them were observed conti nuously, 16 cases were contrasted before and after operation,23 cases and patients' prognosis were analysed.Results Serum EDLS increased within 24 h after brain trauma of different degree in all patients with brain injuries of various intensities.The group of slight injury was the most typal,EDLS demonstrated no change or decrease in a few patients with the injury intensity growing;In most cases EDLS decreased after brain operation or accompaning the wounded recovery; Contents of EDLS at 24 h among different pathological types of brain injuries showed no difference, but in the successful recovery patients with severe or ultra severe brain injuries, EDLS contents at 72 h posttrauma were lower than in the patients of death or disability. The above change characteristics of EDLS related to injury locations and the degree of brain injury.Conclusion EDLS change of dynamic monitoring might reflect the condition of the injury and the prognosis.