| 糖尿病患者红细胞膜磷脂成分的改变 |
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| 引用本文： | 邓华聪 邱鸿鑫. 糖尿病患者红细胞膜磷脂成分的改变[J]. 中华内分泌代谢杂志, 1994, 10(3): 145-147 |
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| 作者姓名： | 邓华聪 邱鸿鑫 |
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| 作者单位： | 重庆医科大学附属第一医院内科内分泌组 |
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| 摘 要： | 应用高效液相色谱法分析７２例ＮＩＤＤＭ患者红细胞膜磷脂成分。结果显示，ＮＩＤＤＭ患者红细胞膜磷脂酰乙醇胺、磷脂酰肌醇、磷脂酰丝氨酸、磷脂酰胆碱、神经鞘磷脂均显著降低，而溶血磷脂酰胆碱显著增高，并且红细胞膜磷脂成分的改变与空腹血糖、糖化血红蛋白、血脂及过氧化脂质有关。提示糖尿病代谢紊乱与脂质过氧化可能是导致红细胞膜磷脂成分改变的重要因素。
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| 关 键 词： | Ⅱ型糖尿病，红细胞膜，磷脂成分 |
CHANGESIN PHOSPHOLIPID COMPOSITION OF ERYTHROCYTE MEMBRANE IN NIDDM |
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| Deng Hua-cong,Qiu Hong-xin,Wang Shu-ping,et al.. CHANGESIN PHOSPHOLIPID COMPOSITION OF ERYTHROCYTE MEMBRANE IN NIDDM[J]. Chinese Journal of Endocrinology and Metabolism, 1994, 10(3): 145-147 |
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| Authors: | Deng Hua-cong Qiu Hong-xin Wang Shu-ping et al. |
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| Affiliation: | Deng Hua-cong,Qiu Hong-xin,Wang Shu-ping,et al.Dept.of Medicine,The First Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing 630042 |
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| Abstract: | The phospholipid compositions of erythrocyte membrane in 72 non-insulin-de pendent diabetes mellitus were determined withHPLC analysis.A significant decrease in phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylcholine,and a sphingomyelin and a significant increase in lysophosphatidylcholine were detected in the NIDDM patients when compared withthe normal controls. These changes in phospholipid compositions of erythrocyte membrane correlated with the fasting blood glu-cose, glycosylated hemoglobin, cholesterol , triglyceride, HDL-C, HDL2-C, HDL3-C, LDL-C and lipid peroxide, It suggests that themetabolic disturbances of diabetes mellitus and lipid peroxidation may contribute to the alteration of the erythrocyte membranephospholipid compositions. |
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| Keywords: | Diabetes mellitus non-insulin-dependent Phospholipid Erythrocyte membrane |
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