| 精氨酸加压素对内毒素诱生内生致热原生成及致热性的影响 |
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| 引用本文： | 杨永录 张犁. 精氨酸加压素对内毒素诱生内生致热原生成及致热性的影响[J]. 中国人兽共患病杂志, 1994, 10(6): 32-34 |
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| 作者姓名： | 杨永录 张犁 |
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| 作者单位： | 解放军兰州医学高等专科学校 |
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| 摘 要： | 本文观察了精氨酸加压素（ａｒｇｉｎｉｎｅｖａｓｏｐｒｅｓｓｉｎ，ＡＶＰ）对体外培育的家兔血细胞生成内生致热原（ｅｎｄｏｇｅｎｏｕｓｐｙｒｏｇｅｎ，ＥＰ）及体内ＥＰ性发热的抑制作用。实验结果如下：１．给家兔分别静脉注射不同培养条件下获得的ＥＰ或ＥＰ＿ａ。ＥＰ＿ａ是在培养过程中加入ＡＶＰ而获得的。结果显示，ＥＰ＿ａ组发热效应明显低于ＥＰ组（Ｐ＞０．０５）。２．静脉注射ＥＰ＋ＡＶＰ组的发热效应比ＥＰ组明显降低（Ｐ＜０．００１）。实验结果表明，ＡＶＰ退热作用的机理之一可能是由于ＡＶＰ抑制了内毒素（ｅｎｄｏｔｏｘｉｎ，ＥＴ）诱生ＥＰ的生成和对抗了ＥＰ的致热活性所致。
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| 关 键 词： | 精氨酸加压素，内生致热原，发热，退热作用 |
The Effect of Arginine Vasopressin on the Production of Endogenous Pyrogen and Pyrogenicity Induced by Endotoxin. |
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| Yang Yonglu,et al. The Effect of Arginine Vasopressin on the Production of Endogenous Pyrogen and Pyrogenicity Induced by Endotoxin.[J]. Chinese Journal of Zoonoses, 1994, 10(6): 32-34 |
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| Authors: | Yang Yonglu et al |
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| Abstract: | The experiment was designed to study the effect of arginine vasopressin(AVP)on the production and pyrogenicity of endogenous pyrogen(EP)in rabbits.The results were as follows:(1)The intravenous injection of EP_a(cultured with AVP)resulted in attenuation of fever magnitude,compared with that of the EP group(P<0.05).(2)The febrile response of EP AVP administered in intravenous injection on rabbits were much lowered than that of the EP group(P<0.001).The experimental results suggested that one of the mechanisms of antipyretic action of AVP might be that AVP inhibits the endotoxin,induces EP production and is resistant to the pyretic activity by EP. |
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| Keywords: | Arginine vasopressin Endogenous pyrogen Fever Antipyretic. |
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