Response of the laboratory mouse to selection for resistance to insecticides |
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| Authors: | F E Guthrie R J Monroe C O Abernathy |
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| Affiliation: | 1. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China;2. Global Product Stewardship, The Procter and Gamble Company, 8700 Mason Montgomery Road, Mason, OH, 45040, United States;3. Key Laboratory of Poyang Lake Environment and Resource Utilization, Ministry of Education, School of Environmental and Chemical Engineering, Nanchang University, Nanchang, 330031, China;1. Graduate School of Natural Science and Technology, Kanazawa University, Kakuma, Kanazawa, 920-1192, Japan;2. Department of Soil Science, Hajee Mohammad Danesh Science and Technology University, Dinajpur, 5200, Bangladesh;3. Institute of Science and Engineering, Kanazawa University, Kakuma, Kanazawa, 920-1192, Japan;4. Institute of Environmental Radioactivity, Fukushima University, 1 Kanayagawa, Fukushima City, Fukushima, 960-1296, Japan |
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| Abstract: | White laboratory mice (Mus musculus) were subjected to ip injections of 4 insecticides (carbaryl, dichlorvos, DDT, and dieldrin) at the calculated LD50 doses one time during each generation for 12–14 generations. LD50 studies made at the 5th, 10th, and terminal generations were in general agreement with LD50 levels established prior to the selection experiments. Variables associated with growth and reproduction were unaffected by the selection experiments except that the dieldrin and dichlorvos subcolonies showed slight retardation of weight gains on occasions. The terminal generation was examined (untreated itself but selected for 12–14 generations from ancestors which had been treated once per generation at the calculated LD50 level) for a number of physiological and biochemical variables. No consistent differences were found among the terminal subcolonies with respect to blood cell numbers and types, respiration rate or O2 consumption, vital organ weight, blood cholinesterase activity, liver dichlorvos hydrolysis, or liver aniline hydroxylase activity. The data appear to support the considerable ability of mice to adapt to stress of insecticide pressure. |
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