Hepatectomy for liver metastasis of colorectal cancer |
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Authors: | Jianmin Xu Ye Wei Yunshi Zhong Jia Fan Jian Zhou Lunxiu Qin Li Ren Xinyu Qin |
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Institution: | (1) Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China;(2) Colorectal Cancer Research Center, Fudan University, Shanghai, People’s Republic of China;(3) Department of Surgery, Shanghai Medical College, Fudan University, Shanghai, People’s Republic of China;(4) Department of Hepatic Surgery, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China |
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Abstract: | Objective The objective of this study was to investigate whether hepatic resection (HR) can increase the survival of liver metastasis
of colorectal cancer (CRC).
Materials and methods CRC patients (n = 669) with liver metastasis treated at the Zhongshan Hospital, Fudan University from 1/2000 to 7/2007 were included in the
study to investigate the relationship between HR and cancer survival.
Results CRC patients (n = 669) with liver metastases who had primary tumor resection were grouped in synchronous liver metastasis (SLM; 56.7%, n = 379) and metachronous liver metastasis (MLM) groups (43.3%, n = 290). Hepatic resection rates were lower (32.5%, n = 123) in the SLM than the MLM group (44.8%, n = 130, P < 0.05). The 30-day mortality rate in the MLM (2.3%) was significantly lower than SLM (2.4%) groups. The 5-year survival
rates (36.6%) was same compared to SLM group (33.1%, P > 0.05). One-, 2-, and 3-year survival of stages I and II operation cases were 92.5% vs 86.5%, 0.7% vs 58.0%, and 42.1% vs
44.9% (P > 0.05) in the SLM group, respectively. Recurrence after first hepatic resection associated with a 2.23-fold increased risk
of death (P < 0.01). Incision margins larger than 1 cm and HR for recurrence associated with 34% and 27% (P < 0.05) decreased death risk.
Conclusions Hepatic resection could help the survival of liver metastasis of colorectal cancer, and stage I surgery is safe for this disease.
Xu Jianmin, Wei Ye, and Zhong Yunshi contributed equally to this paper. |
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Keywords: | Colorectal neoplasms Liver Neoplasm metastasis Hepatectomy |
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