C-myc oncogene amplification in ductal carcinoma in situ of the breast |
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Authors: | Aulmann Sebastian Bentz Martin Sinn Hans Peter |
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Affiliation: | (1) Department of Pathology, University of Heidelberg, Germany;(2) Department of Internal Medicine III, University of Ulm, Germany |
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Abstract: | The c-myc oncogene is frequently activated in invasive breast cancer and has been associated with high nuclear grade, lymph node metastasis and poorer disease outcome. We have examined c-myc oncogene amplification using fluorescence in situ hybridization in a series of 96 pure DCIS. Additionally we assessed amplification and expression of the Her2 and bcl-2 oncogenes. The findings were compared with clinicopathological data, Ki-67 proliferative index and hormone receptor status. We observed c-myc oncogene amplification in 19 tumours (20%). These cases were significantly associated with an average of 38% higher proliferative activity (p = 0.045), a 43% larger tumour size (p = 0.029) and the otherwise rare micropapillary subtype (p = 0.0005). Concluding the c-myc oncogene appears to be involved in the development of a more aggressive phenotype of DCIS. |
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Keywords: | bcl-2 c-myc DCIS FISH Her2 |
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