三七总皂甙在脑出血早期应用的临床意义

目的观察三七总皂甙在脑出血早期应用的临床意义。方法68例急性脑出血患者分为治疗组和对照组,两组均在入院第1、第7、第14、第30天进行血肿、血肿周围水肿及神经功能缺损评分比较,第30天进行临床疗效比较。结果发病第7天:两组血肿均无改变,治疗组血肿周围有轻度水肿,对照组血肿周围水肿明显;发病第14天:治疗组血肿有所吸收。血肿周围水肿明显缩小,对照组血肿吸收不明显,血肿周围水肿有所缩小;发病第30天:治疗组大部分患者血肿完全吸收,大部分患者血肿周围水肿消失,对照组部分患者血肿完全吸收,部分患者血肿周围水肿消失。两组神经功能缺损评分第14、第30天治疗组明显低于对照组(P<0.01)。发病第30天治疗组和对照组的总有效率分别为91.2%和70.6%(P<0.05)。结论三七总皂甙在脑出血早期应用可延迟脑出血后血肿周围水肿的形成,显著缩短水肿的消失时间,并能促进血肿的吸收及神经功能的恢复,明显改善预后。

Clinical Effect of PNS on Encephalorrhagia Application in Earlier Period

Objective To study the effects of Panax notoginseng saponins(PNS)in the patients with acute intracerebral hemorrhage. Methods 68 cases with intracerebral hemorrhage were divided into treatment group and control group.The two groups compared with hematomal,perihematomal edema and neurologic impairment score on the 1st day,7th day,14th day and 30th day.We study the clinical effect on the 30th day.Results On the 7th day,the hematoma in two groups hardly changed,the treatment group had gentle edema,and the edema zone of the control was clear.On the 14th day,the hematoma in treatment group was partly absorbed,but in control the absorption was not obvious;in treatment group the perihematomal edema zone was smaller than in control.On the 30th day,the hematoma of most patients in treatment group and some of in control was completely absorbed; the edema zone of most patients in treatment group and some of in control disappeared.Neurologic impairment score of the treatment is lower than the control's on the 14th day and the 30th day(P<0.01).The utility rate of treatment group and control group were respectively 91.2% and 70.6%(P<0.05).Conlusions PNS can delay the emerge of perihematomal edema if it was applicated in earlier period.It can significantly shorten the recovery time of absorbing edema,and it can facilitate the absorption of hematoma and the restoration of neurologic function.In the end,it can ameliorate prognosis.