唑来膦酸治疗老年女性骨质疏松性骨折的研究

目的 研究唑来膦酸治疗老年女性骨质疏松性骨折的疗效。方法 选择2009年至2010年住院的60岁以上女性长骨骨折患者192例检测BMD，分为治疗组和对照组，两组均在治疗骨折同时给予钙剂和骨化三醇治疗，治疗组于术后1-2周给予唑来膦酸5mg静脉滴注。术后每12个月复查并记录腰椎部骨密度变化，同时观察术后骨折愈合情况、3年内再骨折率的差异。结果 在治疗三年后治疗组骨密度较对照组均有所提高，且差异有统计学意义（p<0.05）；术后三年内治疗组再骨折率低于对照组，且差异有统计学意义（p<0.05）；在骨折愈合方面两组随访3月骨折均愈合良好，结果差异无统计学意义（p>0.05）。结论 唑来膦酸可以有效降低老年女性骨质疏松性骨折患者的再骨折率、提高骨密度，且并不影响骨折愈合。

Efficacy of zoledronic acid in the treatment of elderly women with osteoporotic fractures

Objective To study the curative effect of zoledronic acid on osteoporotic fractures in elder women. Methods A total of 192 patients, aging over 60 years, with osteoporotic fractures were enrolled and assigned into 2 groups from 2009 to 2010. Patients in both groups received Caltrate D and Calcitriol while receiving fracture treatment. Patients in the treatment group received 5 mg zoledronic acid infusion 1-2 weeks after the operation. Bone mineral density (BMD) of the lumbar spine was measured using dual-energy X-ray absorptiometry (DXA) every 12 months after the operation. Fracture healing and the rate of second fractures in 3 years were also observed. Results The BMD in treatment group was significantly higher than in control group (P<0.05) in the 3-year treatment period. The rate of second fractures in treatment group was obviously lower than in control group, with statistical significance (P<0.05). And the fractures healed well in both groups within 3-month follow-up. Conclusion Zoledronic acid can significantly reduce the rate of second fractures, improve BMD in elderly women, with no influence in the fracture healing.