人乳头瘤病毒感染与阴道微生态的相关性研究

目的 越来越多的研究表明,阴道微生态可能在人乳头瘤病毒(HPV)感染易感性中发挥关键作用.本研究的目的是评估阴道微生态与HPV感染的关系.方法 选取2019年6月至2019年12月在重庆市妇幼保健院妇女保健科进行体检的1 000名30 ～ 65岁女性.受检者均常规进行阴道微生态评估和HPV分型检测.根据HPV分型检测结...

Association between the vaginal microecology and Human Papillomavirus infection

Abstract: Objective To evaluate the relationship between the vaginal microecology and HPV infection as accumulating evidence indicates that the vaginal microecology may play a critical role in the susceptibility to Human Papillomavirus ( HPV)infection. Methods A total of 1 000 women aged between 30 and 65 years who underwent physical examination in the Women Health Care Department of Chongqing Maternal and Child Health － Care Hospital from June 2019 to December 2019 was enrolled in our study. Participants were routinely tested for the vaginal microecology and HPV genotyping. Thereafter they were divided into the following two groups according to the results of HPV screening: 1. HPV positive group ( HPV + group，n =235) ; 2. HPV negative group ( HPV － group，n = 765) . The Chi － square test was used to investigate the difference in thevaginal microecology between HPV + women and HPV － women. Results We found a higher rate of vaginal pH value ＞ 4. 5( 57. 87% vs 35. 16% ，OR = 2. 05，95% CI = 1. 22 － 2. 87) ，a higher prevalence of bacterial vaginosis ( 15. 74% vs 9. 41% ，OR = 2. 23，95% CI = 1. 34 － 3. 15) ，a higher rate of abnormal vaginal flora density ( 63. 40% vs 33. 07% ，OR = 1. 94，95%CI = 1. 32 － 2. 56) and a higher rate of?abnormalvaginal flora diversity ( 65. 53% vs 31. 37% ，OR = 1. 89，95% CI = 1. 12 －2. 63) in the group of HPV + women compared to the HPV － group，and there were statistically significant differences. However， no difference was observed in the prevalence of trichomonas vaginitis and vulvovaginal candidiasis between the two groups. Conclusion Vaginal microecology has a significant association with HPV infection. A high vaginal pH value，BV andan abnormal vaginal flora density and diversity increase the susceptibility to HPV infection.