基于关联规则的脂肪肝与5种慢性代谢性疾病的关联性分析

目的 探讨体检人群中高血压、超重肥胖、血脂异常、高尿酸、糖尿病等5种慢性代谢性疾病与脂肪肝的关系，为脂肪肝和慢性代谢性共患病的防治提供依据。方法 采用二分类logistic回归分析脂肪肝患病的危险因素；运用Apriori算法进行年龄别和性别分组的5种慢性代谢性疾病与脂肪肝关联规则挖掘。结果 研究人群中，高血压、超重肥胖、血脂异常、高尿酸、糖尿病、脂肪肝的患病率分别为32.0%、52.0%、34.7%、31.8%、9.9% 和43.4% ；高血压、超重肥胖、血脂异常、高尿酸、糖尿病均是脂肪肝患病的危险因素 (P<0.001，OR值>1)；5种慢性代谢性疾病单独患病对脂肪肝患病的提升度均大于1 (1.42~1.66)；年龄、性别分组后按置信度排名第1的强关联规则均为{高血压，超重肥胖，血脂异常，高尿酸}→{脂肪肝}；不同年龄组和不同性别组在强关联规则个数、关联强度等方面存在差异。结论 高血压、超重肥胖、血脂异常、高尿酸、糖尿病等5种慢性代谢性疾病均可单独对脂肪肝患病起到提升作用，多种疾病共患可增加脂肪肝患病的风险。

Association analysis of fatty liver disease and 5 chronic metabolic diseases based on association rules

To explore the relationship between fatty liver disease and 5 kinds of chronic metabolic diseases，including hypertension，overweight and obesity，dyslipidemia，hypeluricemia and diabetes，in order to provide the basis for theprevention and treatment of fatty liver disease and chronic metabolic mutimorbidities. Methods The risk factors of fatty liverdisease were analyzed by logistic regression. The Apriori algorithm was used to explore the association rules of 5 kinds ofchronic metabolic diseases and fatty liver disease within age and gender groups. Ｒesults In the study population，theprevalence of hypertension，overweight and obesity，dyslipidemia，hypeluricemia，diabetes and fatty liver disease wasrespectively 32. 0% ，52. 0% ，34. 7% ，31. 8% ，9. 9% and 43. 4% . Hypertension，overweight and obesity，dyslipidemia，hypeluricemia and diabetes were all risk factors for fatty liver disease ( P ＜ 0. 001，OＲ value ＞ 1) . The prevalence of 5 kinds ofchronic metabolic diseases alone increased the incidence of fatty liver disease more than 1 ( 1. 42 － 1. 66) . After age andgender grouping，the strong association rules ranked the first in terms of confidence were { hypertension，overweight andobesity，dyslipidemia，hypeluricemia} →{ fatty liver disease} . There are differences in the number of strong association rulesand the strength of association among different age and gender groups. Conclusion Five kinds of chronic metabolic diseases，including hypertension，overweight and obesity，dyslipidemia，hypeluricemia and diabetes，can all independently promote fattyliver disease，and the co － occurrence of multiple diseases can increase the risk of fatty liver disease