新型冠状病毒肺炎与吸烟的相关性研究进展

目的 着重从新型冠状病毒肺炎（Coronavirus disease 2019 ,COVID-19）患者的吸烟率、吸烟对COVID-19患者预后的影响、吸烟与严重急性呼吸综合征冠状病毒2（Severe acute respiratory syndrome coronavirus 2，SARS-CoV-2）感染机制这三个层面阐述了COVID-19与吸烟的最新潜在关系，为COVID-19与吸烟关系的进一步研究提供理论参考。方法 提取世界卫生组织报道的COVID-19最新资料，检索PubMed和中国知网数据库2000年至2021年间收录的与吸烟和COVID-19相关的文章进行综述。结果 吸烟的COVID-19患者发展为重症和出现死亡的风险更高，但关于COVID-19在吸烟者中的发病率是否比非吸烟者高，即吸烟是否会增加SARS-CoV-2感染风险，尚无定论和结论。结论 目前关于COVID-19与吸烟的研究仍处于初级阶段，在将来需要完善更多的分子、细胞水平实验和进行更严谨的调查研究，这将使COVID-19患者获益，尤其是吸烟的COVID-19患者。

Advances in research on COVID-19 and smoking

To analyze smoking rate of COVID-19(Coronavirus disease 2019) patients, the effect of smoking on the prognosis of COVID-19 patients, smoking and the infection mechanism of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) these three aspects to illustrate the latest potential relationship between COVID-19 and smoking, and to provide theoretical reference for further research on COVID-19 and smoking. Methods The latest data of COVID-19 reported by the World Health Organization were extracted, and articles related to smoking and COVID-19 included in PubMed and CNKI database from 2000 to 2021 were reviewed. Results Smoking patients with COVID-19 had a higher risk of developing severe disease and death, but there was no conclusion as to whether the incidence of COVID-19 was higher among smokers than non-smokers, and to whether smoking increased the risk of SARS-CoV-2 infection. Conclusion Current research on COVID-19 and smoking is still in the preliminary stage, and more molecular and cellular experiments and more rigorous investigations are needed in the future, which will benefit COVID-19 patients, especially those who smoke.