主观认知下降患者不同BMI水平与执行功能的相关性研究

目的 探讨主观认知下降（SCD）患者不同BMI水平与执行功能之间的相关性，及影响BMI的危险因素。方法 招募福建省福州市5个社区符合要求的174例SCD患者，根据BMI水平分为正常体质量组（18.5kg/m²≤BMI＜24kg/m²）、超重和肥胖组（24kg/m²≤BMI≤36.5kg/m²），并进行问卷调查、身体测量和Stroop色词测验。采用单因素分析比较不同BMI水平SCD患者执行功能，采用二元logistic回归模型分析影响SCD患者BMI的危险因素。结果 与正常体质量组相比，超重和肥胖组Stroop干扰量（SIE）反应时更长，差异有统计学意义（P＜0.05）。二元logistic回归分析发现，男性患超重和肥胖的风险高于女性（OR=2.204, 95%CI:1.086~4.475, P=0.029），高血压患者患超重和肥胖的概率是无高血压患者的3.060倍（OR=3.060, 95%CI:1.194~7.838，P=0.020）。结论 与正常体质量组相比，超重和肥胖的SCD患者执行功能更差，而且受性别和高血压的影响。对男性SCD患者，控制高血压和体重可能可以有效预防其执行功能下降，降低患AD的风险。

Correlation between different BMI levels and executive function in patients with subjective cognitive decline

To explore the correlation between different BMI levels and executive function in patients with subjectivecognitive decline，and the risk factors affecting BMI. Methods A total of 174 patients with SCD who met the requirementsfrom 5 communities in Fuzhou，Fujian were recruited and divided into normal body mass group( 18. 5kg /m2≤BMI ＜ 24kg /m2) ，overweight and obesity group ( 24kg /m2≤BMI≤36. 5kg /m2) according to their BMI level. The questionnaire survey，body measurement and Stroop Color Word Test were conducted. Univariate analysis was used to compare the executive functionof SCD patients with different BMI levels，and binary logistic regression model was used to analyze the risk factors affecting BMIin SCD patients. Ｒesults Compared with the normal body mass group，the overweight and obesity group had longer StroopInterfere Effects ( SIE) response time，and the difference was statistically significant ( P ＜ 0. 05) . Binary logistic regressionanalysis found that the risk of overweight and obesity in men was higher than that in women ( OＲ = 2. 204，95% CI: 1. 086 －4. 475，P = 0. 029) ，and the probability of overweight and obesity in patients with hypertension was 3. 060 times of patientswithout it ( OＲ = 3. 060，95% CI: 1. 194 － 7. 838，P = 0. 020) . Conclusion Compared with SCD patients with normal bodymass，overweight and obese SCD patients have worse executive function and are affected by gender and hypertension. In menwith SCD，controlling hypertension and weight may be effective in preventing the decline of executive function and reducing therisk of AD