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CROSS-REACTIVITY OF METOCURINE, ATRACURIUM, VECURONIUM AND FAZADINIUM WITH IgE ANTIBODIES FROM PATIENTS UNEXPOSED TO THESE DRUGS BUT ALLERGIC TO OTHER MYONEURAL BLOCKING DRUGS |
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| Authors: | HARLE, D. G. BALDO, B. A FISHER, M. M. |
| Affiliation: | Kolling Institute of Medical Research Department of Medicine, University of Sydney, Sydney, Australia. Intensive Therapy Unit, Royal North Shore Hospital of Sydney, St Leonards, N.S.W., 2065 |
| Abstract: | An inhibition assay was used to determine quantitatively theallergenic cross-reactivity of some myoneural blocking drugsnot yet released for use in Australia, in the sera of patientswho had experienced anaphylactic reactions to neuromuscularblocking drugs. Two of the compounds, metocurine and atracuriumwere highly cross-reactive with the currently used myoneuralblockers; fazadinium was weakly cross-reactive and vecuroniumintermediate in potency between these two extremes. From theseresults, we predict that anaphylactic reactions to these compounds,and particularly to metocurine and atracurium, will occur insome patients allergic to the currently used neuromuscular blockingagents. |
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