| 三阴性乳腺癌的靶向治疗 |
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| 引用本文： | 赵月光,盛苗苗,王芳,李珊珊,戴文珠,罗瑛,唐文如. 三阴性乳腺癌的靶向治疗[J]. 医学分子生物学杂志, 2017, 14(2). DOI: 10.3870/j.issn.1672-8009.2016.02.010 |
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| 作者姓名： | 赵月光 盛苗苗 王芳 李珊珊 戴文珠 罗瑛 唐文如 |
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| 作者单位： | 昆明理工大学医学院衰老与肿瘤分子遗传学实验室 昆明市,650500 |
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| 基金项目： | 国家自然科学基金，云南省省级人培项目(No.KKSY201560001)This work was supported by grants from the National Natural Science Foundation of China，the Natural Science Foundation of Yunnan Province |
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| 摘 要： | 三阴性乳腺癌是一类异质性肿瘤,具有复发早、高侵袭及预后差的特点.三阴性乳腺癌的内分泌和HER2靶向治疗效果甚微.目前,三阴性乳腺癌的治疗以化疗为主,疗效也不佳.然而,随着三阴性乳腺癌的分子分型和肿瘤分子生物学研究,靶向研究在TNBC的治疗中取得了很大的进展.文章就TNBC的分子分型和靶向治疗的最新研究作一综述.
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| 关 键 词： | 三阴性腺乳癌 分子分型 靶向治疗 单克隆抗体 抑制剂 |
Targeted Therapy for Triple Negative Breast Cancer |
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| ZHAO Yueguang,SHENG Miaomiao,WANG Fang,LI Shanshan,DAI Wenzhu,LUO Ying,TANG Wenru. Targeted Therapy for Triple Negative Breast Cancer[J]. Journal of Medical Molecular Biology, 2017, 14(2). DOI: 10.3870/j.issn.1672-8009.2016.02.010 |
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| Authors: | ZHAO Yueguang SHENG Miaomiao WANG Fang LI Shanshan DAI Wenzhu LUO Ying TANG Wenru |
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| Abstract: | Triple negative breast cancer (TNBC) is a heterogeneous tumor characterized by early recurrence,high invasion and poor prognosis.The endocrine therapy or HER2 targeted therapy is not effective for TNBC.Currently,the treatment of this subgroup mainly rely on chemotherapy with suboptimal efficacy achieved.However,with the increasing studies on TNBC subtypes and tumor molecular biology,great progress has been made in targeted therapy for TNBC.Here,we review the latest researches on the subtypes of TNBC and relevant targeted therapies. |
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| Keywords: | triple negative breast cancer molecular subtype targeted therapy monoclonal antibody inhibitor |
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