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舒立迭吸入治疗24例支气管哮喘的疗效及诱导痰中炎症介质的变化
引用本文:吴峰,刘青,周黎明,黄峥惠,陈丽敏,李志鹰.舒立迭吸入治疗24例支气管哮喘的疗效及诱导痰中炎症介质的变化[J].福建医科大学学报,2005,39(4):425-428.
作者姓名:吴峰  刘青  周黎明  黄峥惠  陈丽敏  李志鹰
作者单位:1. 福建医科大学,附属协和医院呼吸内科,福州,350001;福建医科大学,附属协和医院变态反应性疾病中心,福州,350001
2. 福建医科大学,附属协和医院呼吸内科,福州,350001
基金项目:福建省青年科技人才创新基金
摘    要:目的观测舒立迭治疗期间支气管哮喘(哮喘)患者诱导痰中炎症介质浓度变化及其与哮喘临床症状的关系.方法以24例哮喘患者(哮喘组)和9例健康者(对照组)做为研究对象.测定呼气峰值流量(PEF),同时进行诱导痰收集,并测定痰中炎症介质浓度.哮喘组在治疗开始后1,3,6个月时进行重复测定.半胱氨酰白三烯(sLT)以EIA检测箱测定,水溶性介质以ELISA检测箱测定.结果哮喘组诱导痰中sLT显著升高(P<0.05),但激素吸入治疗过程中未见显著性变化.哮喘组痰中各细胞因子浓度升高(均为P<0.05).舒立迭治疗后3个月,PEF值明显改善(P<0.01),白细胞介素(IL)6、10浓度显著升高(均为P<0.05),嗜酸细胞阳离子蛋白(ECP)浓度显著降低(P<0.05);6个月后上述变化更为显著,干扰素(IFN)γ及肿瘤坏死因子(TNF)α浓度出现显著性降低(均为P<0.05),与治疗1个月后相比显著发生变化(均为P<0.05).结论sLT、IL-10与激素治疗之间未见明显的相关.使用舒立迭治疗哮喘应至少连用3个月或以上.

关 键 词:哮喘  舒立迭  炎症介导素类  
文章编号:1672-4194(2005)04-0425-04
收稿时间:2004-12-24
修稿时间:2005-07-26

Change of Inflammation Mediators in Sputum from Asthma Patients Treated by Seretide
WU Feng,LIU Qing,ZHOU Li-ming,HUANG Zheng-hui,CHEN Li-min,LI Zhi-ying.Change of Inflammation Mediators in Sputum from Asthma Patients Treated by Seretide[J].Journal of Fujian Medical University,2005,39(4):425-428.
Authors:WU Feng  LIU Qing  ZHOU Li-ming  HUANG Zheng-hui  CHEN Li-min  LI Zhi-ying
Institution:1. Department of Respiratory; 2. Centaral Institution of Allergology Diseases, The Affiliated Union Hospital, Fujian Medical University, Fuzhou 350001, China
Abstract:Objective To observe the changes of mediators concentration in sputum from patients with asthma and their correlations to asthma clinical symptom in seretide treatment.Methods 24 asthmatics and 9 normal controls were enrolled in this study.In same time with measured the peak of expiratory flow(PEF) value,to collect induced sputum,for analyze mediators concentration.And after treatment 1,3,6 months took remeasurement again.Sulfidopeptide-leukotrienes(sLT) measurement was performed with EIA kit,and water-solubility chemokine was measured with ELISA kit.Results sLT concentration level significant elevated in asthmatic groups(P<0.05),but no significant change was shown during steroid therapy.After 3 months,PEF value was improvement significantly(P<0.01),interleukin(IL) 6,10 concentration levels significant elevated(all were P<0.05),eosinophil cationic protein(ECP) concentration was fall(P<0.05).After 6 months,the changes of these cytokines were more marked,and interferon(IFN) gamma and tumor necroses factor(TNF) alpha concentrations falled significantly(all were P<0.05).Conclusion sLT and IL-10 do not show significant change to steroid therapy,unless 3 months treatment had been taken.
Keywords:asthma  seretide  inflammation-mediators  sputum
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