Targeted therapies in bone sarcomas: current approach and future directions |
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Authors: | Yarber Jessica Lee Agulnik Mark |
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Institution: | Northwestern Memorial Hospital, Internal Medicine, Chicago, IL 60611, USA. yarberjl@gmail.com |
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Abstract: | INTRODUCTION: Bone sarcomas are rare malignancies and once advanced, there is limited response to current chemotherapeutic regimens. Targeted therapies could have substantial impact on these diseases. AREAS COVERED: Specific molecular targets of bone sarcomas are reviewed along with the various targeted therapies that have potential to change the outcome of these chemotherapy resistant diseases. EXPERT OPINION: There are promising pathways identified that targeted inhibitors could provide better treatment options for metastatic bone sarcomas. There is a strong need for continued Phase II and III clinical trials investigating these molecularly targeted therapies. |
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