Neutrophil granulocyte derived MMP-9 is a VEGF independent functional component of the angiogenic switch in pancreatic ductal adenocarcinoma |
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| Authors: | Dirk Bausch Thomas Pausch Tobias Krauss Ulrich Theodor Hopt Carlos Fernandez-del-Castillo Andrew L Warshaw Sarah P Thayer Tobias Keck |
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| Institution: | 1.Department of General and Visceral Surgery,University of Freiburg,Freiburg,Germany;2.Klinik für Allgemein, Viszeral- und Transplantationschirurgie,Universit?t Heidelberg,Heidelberg,Germany;3.Radiologische Universit?tsklinik Freiburg i. Br.,Freiburg i. Br.,Germany;4.Department of Surgery,Massachusetts General Hospital and Harvard Medical School,Boston,USA |
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| Abstract: | Background Vascular endothelial growth factor (VEGF) that is secreted by tumor cells plays a key role in angiogenesis. Matrix metalloproteinase
9 (MMP-9) is produced by inflammatory cells, such as stromal granulocytes (PMN), remodels the extracellular matrix and is
known to promote angiogenesis indirectly by interacting with VEGF. The aim of this study was to determine the role of PMN-derived
MMP-9, its interaction with VEGF, and the efficacy of anti-angiogenic therapy targeting MMP-9 with oral Doxycycline and VEGF
with Bevacizumab in pancreatic cancer (PDAC). |
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