| 霍奇金淋巴瘤潜伏膜蛋白1、p53及bcl—2蛋白的表达及意义 |
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| 引用本文： | 齐宗利,赵彤,等.霍奇金淋巴瘤潜伏膜蛋白1、p53及bcl—2蛋白的表达及意义[J].第一军医大学学报,2003,23(3):225-227. |
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| 作者姓名： | 齐宗利 赵彤 |
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| 摘 要： | 目的：探讨EB病毒潜伏膜蛋白（LMP）,p53,bcl-2的蛋白表达在霍奇林巴瘤（HP）致病机制中的作用及其意义。方法：对收集的31例石蜡包埋的HP组织进行LMP1，p53,bcl-2蛋白免疫组化染色。结果：LMP1，p53,bcl-2的阳性率分别为58．1％，61．3％，35．5％，LMP1与p53相关性分析具有统计学意义。结论：p53可能参与LMP1与HL致病机制中的作用，bcl-2可能与HL的致病关系不大。
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| 关 键 词： | 霍奇金病 疱疹病毒4型 人 病毒包膜蛋白质类 蛋白质p53 原癌基因蛋白质c－bcl－2 免疫组织化学 |
Expressions of latent membrane protein 1, p53 and bcl-2 proteins and their significance in Hodgkin's lymphoma. |
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| Zong-li Qi,Tong Zhao,Xin-hua Zhou,Jin-hua Zhang,Xi-qun Han,Mei-gang Zhu.Expressions of latent membrane protein 1, p53 and bcl-2 proteins and their significance in Hodgkin''s lymphoma.[J].Journal of First Military Medical University,2003,23(3):225-227. |
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| Authors: | Zong-li Qi Tong Zhao Xin-hua Zhou Jin-hua Zhang Xi-qun Han Mei-gang Zhu |
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| Institution: | Department of Pathology, First Military Medical University, Guangzhou 510515, China. qizongli@sina.com |
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| Abstract: | OBJECTIVE: To study the expressions of latent membrane protein 1 (LMP1), p53 and bcl-2 proteins and investigate their significance in the pathogenesis of Hodgkin's lymphoma. METHODS: Immunohistochemical staining was used to examine the expressions of LMP1, bcl-2, and p53 proteins in 31 paraffin-embedded tissue samples from Hodgkin's lymphoma. RESULT: The positivity rates of LMP1, p53 and bcl-2 proteins were 58.1% (18/31), 61.3% (19/31) and 35.5% (11/31), respectively, showing a statistically significant difference between the expressions of the former 2 proteins. CONCLUSION: p53 may be involved as an important agent in the pathogenesis of Hodgkin's lymphoma induced by LMP1, whereas bcl-2 appears unrelated to the development of this disease. |
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